Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Epirubicin is an anthracycline chemotherapy medicine, a close relative of doxorubicin with somewhat less effect on the heart at equal strength. It slips between DNA strands and blocks topoisomerase II. It is used mainly for breast cancer, often in combinations such as FEC, and for stomach cancer. It is sold as Ellence and Pharmorubicin, among other names.
Epirubicin is cleared mainly by UGT2B7, unlike other anthracyclines. Gene studies listing it, mostly in breast cancer treated with several medicines at once, looked at GSTP1, NQO1, CBR3 and others for response and side effects such as low white cell counts and heart damage, and a genome-wide study flagged PIK3R2. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Epirubicin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
NOS3 rs1799983: Level 3. Efficacy: Neoplasms, Ovarian Neoplasms, Stomach Neoplasms. 2.
PIGB rs12050587: Level 3. Toxicity: Breast Neoplasms, Leukopenia, Neutropenia. 1.
GSTP1 rs1695: Level 3. Efficacy: Breast Neoplasms. 1.
GSTP1 rs1695: Level 3. Toxicity: Breast Neoplasms, Drug Toxicity. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Anthracyclines (class) (Anthracyclines)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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