Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Anthracyclines are a class of chemotherapy medicines, first isolated from Streptomyces bacteria, that slip between DNA strands and block topoisomerase II. The class includes doxorubicin, daunorubicin, epirubicin and idarubicin, with the related mitoxantrone, used for breast cancer, leukaemias, lymphomas and sarcomas. Damage to the heart muscle limits the total amount a person can receive. This page collects studies on the class as a group.
Most gene studies on the class concern heart damage, mainly in children treated for cancer: SLC28A3 (rs7853758 is linked to lower risk), RARG and UGT1A6 have the strongest findings, and CBR1 and CBR3, which form cardiotoxic breakdown products, have also been studied. A RARG variant has been proposed for screening in children, but no CPIC or DPWG guideline exists.
Every published finding on gene variants and Anthracyclines. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLC28A3 rs7853758: Level 2B · replicated. Toxicity: Cardiotoxicity. 5.
RARG rs2229774: Level 3. Toxicity: Cardiotoxicity, Neoplasms. 7.
SLC28A3 rs885004: Level 3. Toxicity: Neoplasms. 2.
CBR3 rs1056892: Level 3. Toxicity: Heart Failure, Neoplasms. 2.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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