Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Entacapone is a COMT inhibitor: it blocks catechol-O-methyltransferase outside the brain, so less levodopa is broken down and more reaches the brain. It is taken with each dose of levodopa in Parkinson's disease to reduce 'wearing-off' between doses, also in the combination Stalevo. It can turn urine orange. It is sold as Comtan.
Entacapone acts on COMT itself, and the gene study listed looked at the common COMT Val158Met variant (rs4680), which sets how active the enzyme is, for how much entacapone improved levodopa's effect: people with the high-activity version gained more in that study. The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Entacapone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
COMT rs4680: Level 3. Efficacy: Parkinson Disease. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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