Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Empagliflozin is an SGLT2 inhibitor: it blocks the transporter in the kidney that takes glucose back from the urine, so excess sugar leaves the body. It is used for type 2 diabetes, and, regardless of diabetes, for heart failure and chronic kidney disease, where it reduces hospital admissions and slows decline. It is sold as Jardiance, and with linagliptin or metformin in combinations.
Empagliflozin is cleared mainly by UGT enzymes and the kidneys. The gene studies on it looked at SLC5A2, the gene for the SGLT2 transporter it blocks, for how much glucose the kidneys passed and how much blood sugar fell. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Empagliflozin. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antithyroid Drugs (class) (Antithyroid Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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