Dulaglutide (Trulicity)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Dulaglutide

What it is

Dulaglutide is a GLP-1 receptor agonist, a GLP-1-like peptide joined to part of an antibody so it lasts a week. It mimics the gut hormone GLP-1, so the pancreas releases insulin when blood sugar is high, stomach emptying slows and appetite falls. It is injected weekly for type 2 diabetes, where it also lowers the chance of heart attack and stroke. It is sold as Trulicity.

How genes come into it

As a protein, dulaglutide is broken down like other proteins, not by liver enzymes. A study linked variants in GLP1R, the receptor it acts on, and ARRB1, a protein involved in the receptor's signalling, to how much blood sugar and weight fell. The findings come from a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Dulaglutide. Upload your DNA file to see which of these rows apply to you.

Response (8 findings)

Studies of how well it worked in people carrying a variant.

ARRB1 rs140226575: Allele A is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele G.

ARRB1 rs58428187: Allele C is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele T.

ARRB1 rs78052828: Allele T is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele C.

ARRB1 rs78979036: Allele A is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele G.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Byetta (GLP-1 Agonists)

GLP-1 Agonists (class) (GLP-1 Agonists)

Ozempic (GLP-1 Agonists)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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