Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Tuberculosis medicines are given in combinations for months, because the bacteria grow slowly and become resistant to any single drug. Standard treatment combines isoniazid, rifampicin, pyrazinamide and ethambutol for two months, then isoniazid and rifampicin for four more; newer regimens with bedaquiline, pretomanid and linezolid treat drug-resistant forms. This page collects studies on tuberculosis treatment as a whole.
The strongest gene for tuberculosis treatment is NAT2, which inactivates isoniazid: slow acetylators (two low-activity copies, about half of people of European ancestry) keep higher isoniazid levels and have a higher chance of liver injury during combined treatment. Studies have also looked at CYP2E1, ABCB1 and glutathione transferase genes for liver injury. There is no CPIC or DPWG guideline yet.
Every published finding on gene variants and TB Drugs. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
NAT2 NAT2*1, NAT2*4, NAT2*5, NAT2*6, NAT2*7, NAT2*14, NAT2*16: Level 1B · replicated. Toxicity: Drug-induced liver injury, Toxic liver disease, Tuberculosis. 33.
NAT2 rs1799929: Level 3. Toxicity: Tuberculosis. 8.
CYP2E1 CYP2E1*1A, CYP2E1*5B: Level 3. Toxicity: Tuberculosis. 5.
ABCB1 rs1045642: Level 3. Toxicity: Tuberculosis. 3.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Isoniazid (Antimycobacterials)
Myambutol (Antimycobacterials)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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