Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Dobutamine is a synthetic catecholamine that mainly activates beta-1 receptors in the heart, making it pump more strongly. Given by continuous drip in hospital, it supports the heart in cardiogenic shock and severe heart failure, and is used in stress echocardiography to test how the heart copes with extra work. It was sold as Dobutrex.
Dobutamine is broken down within minutes by COMT and conjugation. The gene studies on it looked at ADRB1, the beta-1 receptor gene (its Arg389Gly variant), and GNAS, which carries the receptor's signal, for how strongly the heart rate and pumping responded. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Dobutamine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GNAS rs62205366: Level 3. Efficacy. 1.
ADRB1 rs1801253: Level 3. Efficacy. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Sympathomimetics (class) (Sympathomimetics)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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