Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Dasatinib is a targeted cancer medicine, a second-generation tyrosine kinase inhibitor that blocks BCR-ABL and SRC family kinases. It is used for chronic myeloid leukaemia (first line or after imatinib) and for Philadelphia chromosome-positive acute lymphoblastic leukaemia. Fluid around the lungs is a known side effect. It is sold as Sprycel.
Whether dasatinib works depends on the BCR-ABL fusion and its mutations in the leukaemia cells, which are acquired, not inherited. For inherited genes, dasatinib is broken down by CYP3A4 and studies looked at the transporter ABCG2. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Dasatinib. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCG2 rs2231137: Level 3. Other. 1.
ABCG2 rs45605536: Level 3. Other. 1.
ABCG2 rs58818712: Level 3. Other. 1.
ABCG2 rs41282401: Level 3. Other. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Apatinib (Tyrosine Kinase Inhibitors)
Gilotrif (Tyrosine Kinase Inhibitors)
Gleevec (Tyrosine Kinase Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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