Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Dalcetrapib is an experimental CETP modulator that raises HDL cholesterol by changing how cholesterol is transferred between lipoproteins. Its large dal-OUTCOMES trial did not reduce heart events overall, and it is being studied further only in people with a particular genotype. It is not approved.
Dalcetrapib is one of the clearest examples of a medicine re-tested by gene. A genome-wide analysis of dal-OUTCOMES found that people with the AA genotype at rs1967309 in ADCY9 had fewer heart events on dalcetrapib, while those with GG had more. A new trial (dal-GenE) tested it only in people with the AA genotype. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Dalcetrapib. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ADCY9 rs1967309: Level 3. Efficacy, Toxicity: Acute coronary syndrome. 2.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antithyroid Drugs (class) (Antithyroid Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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