Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Cytarabine (Ara-C) is a chemotherapy medicine of the antimetabolite group: inside cells it becomes a false building block that stops DNA from being copied. It is a backbone of treatment for acute myeloid leukaemia and is also used for acute lymphoblastic leukaemia and some lymphomas. It is sold as Cytosar-U, among other names.
Studies have looked at genes along cytarabine's path: the carrier that takes it into cells (SLC29A1), the enzymes that activate it (DCK, CMPK1), the enzyme that inactivates it (CDA), and ribonucleotide reductase (RRM1, RRM2). Some CDA variants have been linked to more side effects or to a weaker effect. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Cytarabine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CDA rs2072671: Level 3. Toxicity: Leukemia, Lymphoma. 7.
CDA rs3215400: Level 3. Toxicity. 6.
CDA rs532545: Level 3. Efficacy: Leukemia, Myeloid, Acute, Neoplasms. 4.
CDA rs532545: Level 3. Toxicity: Leukemia, Myeloid. 4.
Studies of how well it worked in people carrying a variant.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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