Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Celecoxib is an anti-inflammatory pain medicine of the COX-2 inhibitor group, a kind of NSAID that blocks mainly the COX-2 enzyme behind inflammation and is gentler on the stomach than older NSAIDs. It is used for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain and period pain. It is sold as Celebrex, among other names.
Celecoxib is broken down mainly by the liver enzyme CYP2C9. People with reduced-function versions such as *3, and especially those with two of them (poor metabolizers), clear it more slowly and have several times higher levels. CPIC has published a guideline on CYP2C9 and the NSAIDs, including celecoxib, and the US drug label addresses CYP2C9 poor metabolizers. A few other genes have been studied, with weaker evidence.
Clinical guidelines that name a gene for Celecoxib. They sort people into groups by the gene copies they carry.
CPIC guideline: CYP2C9. CYP2C9 activity score 0 to 2. Strong. 2020.
US FDA: CYP2C9. CYP2C9 activity score 0 to 0.5. 2024.
Every published finding on gene variants and Celecoxib. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C9 CYP2C9*1, CYP2C9*2, CYP2C9*3, CYP2C9*13: Level 1A · replicated. Metabolism/PK. 7.
CYP2C9 rs1057910: Level 3. Toxicity. 2.
PTGER4 rs4133101: Level 3. Toxicity: Colorectal Neoplasms. 1.
ALOX12 rs11078659: Level 3. Efficacy, Toxicity: Colorectal Neoplasms. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Aldara (Immune Response Modifiers)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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