Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Calcitriol is the active hormone form of vitamin D (1,25-dihydroxyvitamin D), which the kidneys normally make. As a medicine it raises calcium absorption from the gut and lowers parathyroid hormone. It is used in chronic kidney disease, where the kidneys can no longer activate vitamin D, for low parathyroid function, and for some rare forms of rickets; as an ointment, it treats psoriasis. It is sold as Rocaltrol, among other names.
Calcitriol is inactivated mainly by CYP24A1, the enzyme that breaks down active vitamin D. The gene studies on it looked at CYP24A1 variants; people with loss-of-function CYP24A1 variants, which cause a rare inherited condition with high calcium, clear active vitamin D poorly. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Calcitriol. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antithyroid Drugs (class) (Antithyroid Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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