Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Brexpiprazole is an antipsychotic related to aripiprazole: it partly activates dopamine D2 and serotonin 5-HT1A receptors and blocks 5-HT2A receptors. It is used for schizophrenia, as an add-on in major depression, and for agitation in Alzheimer's dementia. It is sold as Rexulti.
Brexpiprazole is broken down by the liver enzymes CYP2D6 and CYP3A4. People with no working CYP2D6 copies (poor metabolizers) have clearly higher exposure, and the US drug label addresses them. DPWG has published a guideline on CYP2D6 and brexpiprazole, and the US FDA lists the pair. Only a few studies have looked at genes for this medicine.
Clinical guidelines that name a gene for Brexpiprazole. They sort people into groups by the gene copies they carry.
DPWG guideline: CYP2D6. CYP2D6 activity score 0 to 6 or more. 2024.
US FDA: CYP2D6. CYP2D6 activity score 0.
US FDA: CYP2D6. CYP2D6 activity score 0. Data that Support Therapeutic Management Recommendations.
Every published finding on gene variants and Brexpiprazole. Upload your DNA file to see which of these rows apply to you.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antipsychotics (class) (Antipsychotics)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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