Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Boceprevir was one of the first direct-acting antivirals for hepatitis C: it blocked the viral NS3/4A protease. Approved in 2011, it was used with peginterferon and ribavirin for genotype 1 hepatitis C and was withdrawn a few years later as better-tolerated, interferon-free medicines replaced it. It was sold as Victrelis.
Response to boceprevir-based treatment depended strongly on the IFNL3 (IL28B) region: people with the CC genotype at rs12979860 cleared the virus much more often, a finding rated at PharmGKB's highest level. This mostly reflects the interferon part of the treatment. Boceprevir itself was broken down by aldo-keto reductases and CYP3A4. There is no CPIC guideline for boceprevir itself.
Every published finding on gene variants and Boceprevir. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
IFNL3;IFNL4 rs12979860: Level 1A · replicated. Efficacy: Chronic hepatitis C virus infection. 5.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Faldaprevir (NS3/4A Protease Inhibitors)
Grazoprevir (NS3/4A Protease Inhibitors)
Incivek (NS3/4A Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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