Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Grazoprevir is a hepatitis C NS3/4A protease inhibitor, given combined with the NS5A inhibitor elbasvir in one daily tablet (Zepatier) for genotype 1 and 4 hepatitis C, including in people with advanced kidney disease.
Grazoprevir is taken into the liver by the transporters SLCO1B1 and SLCO1B3 and broken down by CYP3A4. The gene studies listed looked at SLCO1B1 variants for its levels; medicines that block these transporters, such as ciclosporin, raise grazoprevir much more. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Grazoprevir. Upload your DNA file to see which of these rows apply to you.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Faldaprevir (NS3/4A Protease Inhibitors)
Incivek (NS3/4A Protease Inhibitors)
Olysio (NS3/4A Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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