Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Aspirin (acetylsalicylic acid) permanently blocks the COX enzymes. At low doses it mainly stops platelets from making thromboxane, so it is used to prevent heart attacks and strokes in people at high risk; at higher doses it relieves pain, fever and inflammation. It is one of the most widely used medicines in the world.
No single gene has strong evidence for aspirin. Many studies on this page list CYP2C19 because they followed people taking aspirin together with clopidogrel, whose activation depends on that gene. Others have looked at platelet genes such as PEAR1, ITGA2 and TBXA2R for how strongly aspirin dampens platelets, and at HLA-DPB1*03:01 for aspirin-exacerbated asthma. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Aspirin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
HLA-DPB1 HLA-DPB1*03:01: Level 2B · replicated. Toxicity: Asthma. 3.
ITGA2 rs1126643: Level 3. Efficacy: Coronary Artery Disease, Coronary Disease, Myocardial Infarction. 5.
P2RY1 rs1065776: Level 3. Efficacy: Myocardial Infarction. 3.
LTC4S rs730012: Level 3. Toxicity: Urticaria. 3.
Studies of how well it worked in people carrying a variant.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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