Antihypertensives (class)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Antihypertensives

What it is

Antihypertensives are the medicines used to lower high blood pressure. The main groups are ACE inhibitors (such as ramipril), angiotensin receptor blockers (such as losartan), calcium channel blockers (such as amlodipine), thiazide diuretics (such as hydrochlorothiazide) and beta blockers; many people take two or more together. This page collects studies on blood pressure medicines as a group.

How genes come into it

Studies of the group as a whole, several from large trials, have searched for genes that predict how much blood pressure falls, flagging GRK5, NOS3, ATP2B1, PTPRD and others. None has been confirmed strongly enough to guide treatment, and there is no CPIC or DPWG guideline. Gene findings for individual medicines, such as CYP2D6 for metoprolol, are on their own pages.

What research found

Every published finding on gene variants and Antihypertensives. Upload your DNA file to see which of these rows apply to you.

Rated evidence (7 rated variants)

PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.

GRK5 rs2230345: Level 3. Efficacy: Heart Diseases. 2.

NOS3 rs2070744: Level 3. Efficacy: Hypertension. 1.

ATP2B1 rs12817819: Level 3. Efficacy: Coronary Artery Disease, Hypertension. 1.

CLNK rs13144136: Level 3. Efficacy: Hypertension. 1.

Response (9 findings)

Studies of how well it worked in people carrying a variant.

ATP2B1 rs12817819: Genotypes CT + TT are associated with increased resistance to Antihypertensives in people with Coronary Artery Disease or Hypertension as compared to genotype CC.

CLNK rs13144136: Allele G is associated with increased response to Antihypertensives in people with Hypertension as compared to allele T.

MMP9 rs3918242: Genotype CT is associated with decreased response to Antihypertensives, hydralazine, Methyldopa or nifedipine in people with Gestational hypertension as compared to genotype CC.

AGT rs699: Allele G is not associated with response to Antihypertensives in people with Hypertension.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Accupril (ACE Inhibitors)

ACE Inhibitors (class) (ACE Inhibitors)

Acenocoumarol (Anticoagulants)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

Back to Medications

Content updated September 2026.

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