Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Amoxicillin is a penicillin antibiotic: it blocks the enzymes bacteria use to build their cell wall. It is one of the most prescribed antibiotics, used for ear, sinus, throat, chest, urinary and skin infections, for Lyme disease, and as part of the treatment that clears Helicobacter pylori. With clavulanic acid it is sold as Augmentin; on its own as Amoxil, among other names.
Amoxicillin is cleared mostly unchanged by the kidneys, so drug-processing genes play little part. Many studies listing it are Helicobacter treatments, where CYP2C19 affects the proton pump inhibitor given alongside, not amoxicillin itself. HLA variants such as HLA-DRB1*15:01 and HLA-B have been linked to liver injury with amoxicillin-clavulanate. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Amoxicillin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
HLA-DQB1 rs9274407: Level 3. Toxicity: Drug Toxicity. 1.
HLA-B HLA-B*18:01: Level 3. Toxicity. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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