Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Amisulpride is an antipsychotic that selectively blocks dopamine D2 and D3 receptors. At higher doses it is used for schizophrenia; at low doses, in some countries, for low mood, and as an injection to prevent nausea after surgery (Barhemsys). It is sold as Solian, among other names.
Amisulpride is hardly broken down; the kidneys clear it largely unchanged, so liver-enzyme genes play little part. Studies have looked at the dopamine receptor gene DRD2 and the ANKK1 region, at HTR1A and ANKS1B for response, and at MC4R and SH2B1 for weight gain. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Amisulpride. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
MC4R rs489693: Level 3. Toxicity: Hypertriglyceridemia, Weight gain. 2.
MC4R rs17782313: Level 3. Toxicity: Weight gain. 1.
HTR1A rs10042486: Level 3. Efficacy: Schizophrenia. 1.
SH2B1 rs3888190: Level 3. Toxicity: Bipolar Disorder, Depressive Disorder, Psychotic Disorder, Schizoaffective disorder. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antipsychotics (class) (Antipsychotics)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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