Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Amiloride is a potassium-sparing diuretic: it blocks the sodium channel ENaC in the last part of the kidney tubule, so more sodium leaves in the urine while potassium is kept. It is used with thiazide or loop diuretics to prevent potassium loss, for high blood pressure, and for Liddle syndrome, an inherited form of high blood pressure caused by an overactive ENaC. It is sold as Midamor, among other names.
Amiloride is cleared unchanged by the kidneys, so drug-processing genes play no part. The few gene studies on it looked at CYP4A11, which affects how the kidney handles sodium, and NEDD4L, which controls how long ENaC channels stay active, for blood pressure response. In Liddle syndrome, the variants that cause the condition, in the ENaC genes, are what make amiloride work so well. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Amiloride. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP4A11 rs1126742: Level 3. Efficacy: Hypertension. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
ACE Inhibitors (class) (ACE Inhibitors)
Acenocoumarol (Anticoagulants)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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