ReadYourDNA

Insomnia

Where your DNA places you among other people, and the studies behind it.

General information

Not tailored to your result, and not medical advice

Practice Cognitive Behavioral Therapy for Insomnia (CBT-I): CBT-I is the recommended first-line treatment for chronic insomnia, favored over medication by major guidelines from the American College of Physicians and the American Academy of Sleep Medicine. It targets the thoughts and behaviors that perpetuate insomnia through sleep restriction, stimulus control, cognitive restructuring, and relaxation. Meta-analyses report large average effects, and unlike sleeping pills its benefits tend to be sustained after treatment ends. American College of Physicians

Maintain a Strict Sleep-Wake Schedule: Go to bed and wake up at the same time every day, including weekends. This anchors your circadian clock and strengthens sleep drive. Avoid sleeping in after poor nights - while counterintuitive, this builds sleep pressure for the following night. Consistency is more important than total hours. Sleep Foundation

Optimize Your Sleep Environment: Keep your bedroom cool, dark, and quiet, and clear it of screens and bright lights. Reserving the bed mainly for sleep - a core element of stimulus-control therapy - helps strengthen the association between bed and sleep, so getting up when you cannot sleep is often more useful than lying awake. National Heart, Lung, and Blood Institute

Limit Caffeine and Alcohol: Caffeine has a half-life of 5-7 hours and can disrupt sleep architecture even when consumed 6 hours before bedtime. Avoid caffeine after midday. Alcohol, while sedating initially, fragments sleep during the second half of the night and suppresses REM sleep, leading to unrestorative sleep. Journal of Clinical Sleep Medicine

Use Morning Light Exposure: Bright light exposure (ideally sunlight) soon after waking helps anchor your circadian rhythm and increase daytime alertness. Timed morning light is a recommended, evidence-based tool for advancing sleep timing, and is especially useful for people with a delayed sleep phase. American Academy of Sleep Medicine (practice parameters)

Genetics vs Environment

How much of this is genetic?

Genetics explains 40% of why people differ in this trait. The rest is environment, daily habits and chance.

Heritability estimate: Barclay et al. 2021, Genes Brain Behav

About Insomnia

Background and further reading

Insomnia is the most common sleep disorder. Roughly 10% of adults meet the criteria for chronic insomnia disorder, while around 30% report occasional insomnia symptoms [3]. It is defined by persistent difficulty initiating or maintaining sleep, or waking too early, despite adequate opportunity for sleep, together with daytime consequences. When this pattern lasts three months or more it is considered chronic, and it is associated with daytime fatigue, impaired concentration, and mood disturbance; large genetic analyses also link it to higher risk of depression and cardiometabolic disease, though such observational and Mendelian-randomization signals describe risk rather than certainty [1]. Insomnia is reported more often by women than men.

Genetic Basis: A meta-analysis of twin studies puts the heritability of insomnia at about 40%, with estimates higher in women (around 59%) than men (around 38%) [2]. The trait is strongly polygenic: a 2019 genome-wide study of more than 1.3 million people identified 202 risk loci [1], and a 2022 meta-analysis in over 2.3 million individuals expanded this to 554 loci, many tied to synaptic signaling and neuronal differentiation [4]. One of the most prominent signals sits in the MEIS1 region, a locus also strongly associated with restless legs syndrome; researchers debate how much of its insomnia association reflects a shared biological effect versus phenotypic overlap between the two conditions [5]. The implicated genes converge on brain tissue and neuronal pathways, and there is substantial genetic correlation between insomnia and depression, anxiety, and neuroticism [4].

Environmental Factors: Because twin-based heritability is around 40%, the majority of the variation in insomnia risk reflects non-genetic and environmental influences [2]. Common contributors include psychological stress and worry - particularly worry about sleep itself, which can perpetuate the problem - along with poor sleep hygiene (irregular schedules, evening screen use, caffeine, and alcohol), uncomfortable sleep environments, and circadian disruption from shift work or jet lag [3]. Caffeine taken even six hours before bed can measurably shorten and fragment sleep, reflecting its multi-hour half-life [6]. These behavioral and environmental factors are also where most of the practical opportunity to improve sleep lies.

How this was calculated

The published research behind your score, and the variants it draws on.

Study Details

8 published scores from 4 studies

The insomnia score combines 8 polygenic scores drawn from 4 published studies.

Campos AI (2021). Understanding genetic risk factors for common side effects of antidepressant medications Commun Med (Lond): 2.7M

Zhang Y (2022). Genetic determinants of cardiometabolic and pulmonary phenotypes and obstructive sleep apnoea in HCHS/SOL. EBioMedicine: 850k

Ma Y (2022). ExPRSweb: An online repository with polygenic risk scores for common health-related exposures. Am J Hum Genet: 1.1M

Privé F (2022). Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort Am J Hum Genet: 927k

Sources

Jansen PR, et al. Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways. Nature Genetics (2019)

Barclay NL, et al. The heritability of insomnia: A meta-analysis of twin studies. Genes, Brain and Behavior (2021)

American Academy of Sleep Medicine. ACP recommends cognitive behavioral therapy as initial treatment for chronic insomnia (overview of insomnia prevalence and care). American College of Physicians (2016)

Watanabe K, et al. Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. Nature Genetics (2022)

Lane JM, et al. Reassessing GWAS findings for the shared genetic basis of insomnia and restless legs syndrome. Sleep (2018)

Drake C, et al. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. Journal of Clinical Sleep Medicine (2013)

Related Traits

These traits are influenced by some of the same genes and variants as this one

Depression: Major depressive disorder, a persistent mood condition affecting emotional regulation and daily functioning.

Anxiety: A tendency toward generalized anxiety, chronic worry, and heightened sensitivity to stress.

Neuroticism: A personality dimension reflecting emotional instability, tendency toward negative emotions, and stress sensitivity.

Back to All Traits

Content updated August 2026.

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