What you carry at this position in your DNA and what research says about it.
Cardiac Health and Rhythm: 10/10 evidence, 14 publications.
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Sample genotype (not yours): G/G
Higher Cardiomyopathy and Arrhythmia Risk
Typical cardiac electrical recharge times are paired with an elevated susceptibility to structural heart conditions. This genotype is linked to a higher risk of hypertrophic cardiomyopathy and atrial fibrillation.
What this genotype means: Elevated risk of hypertrophic cardiomyopathy; Increased likelihood of atrial fibrillation; Higher probability of requiring a pacemaker.
Sample genotype (not yours): C/C
Lower Cardiomyopathy Risk with Minor QT Prolongation
A minor delay in the heart's electrical recharge time is accompanied by strong protection against structural heart diseases. This genotype significantly lowers the risk of hypertrophic cardiomyopathy.
What this genotype means: Significantly lower risk of hypertrophic cardiomyopathy; Reduced risk of atrial fibrillation; Minor, typically benign increase in QT interval duration.
Sample genotype (not yours): G/C
Typical Cardiac Risk Profile
A balanced genetic profile results in typical cardiac electrical recharge times and average structural heart risks. This heterozygous state represents the baseline for most cardiovascular outcomes at this locus.
What this genotype means: Typical QT interval duration; Average baseline risk for cardiomyopathy; Standard risk for atrial fibrillation.
Gene function and biological role
Gene Function: The RNF207 gene encodes a heart-specific ring finger protein that plays a critical role in cardiac electrical activity [1]. It interacts with key potassium channels, particularly HERG, to regulate their trafficking and localization in heart muscle cells [2]. By modulating these channels, the protein helps control the duration of the cardiac action potential and the heart's repolarization phase [1]. Proper functioning of this gene is essential for maintaining a stable heart rhythm and preventing structural heart complications [2].
Variant Impact: The rs846111 variant is a missense mutation in the RNF207 gene that changes the amino acid at position 603 from glycine to alanine. This structural alteration directly impacts how the RNF207 protein interacts with cardiac ion channels and chaperone proteins [1]. The change influences the rate at which the heart's ventricles recharge after each beat, measured as the QT interval on an electrocardiogram [3]. Additionally, this variant exhibits a strong pleiotropic effect, simultaneously affecting the risk of structural heart diseases and electrical rhythm disorders [2].
Key Insight: This variant presents a genetic trade-off where the allele that slightly prolongs the heart's electrical recharge time actually protects against major structural heart diseases like hypertrophic cardiomyopathy.
Location: RNF207. Chromosome 1 · 1p36.31 · 6.2 Mb
Estimated prevalence by population
Global 65.1%; European 53.1%; African 89.9%; East Asian 67.3%; South Asian 50.8%; Americas 66.3%; Ashkenazi 54.8%; Finnish 54.5%; Middle Eastern 60.4%; Amish 42.3%.
Estimated GG genotype frequency.
Global 30.0%; European 39.6%; African 9.8%; East Asian 29.5%; South Asian 41.0%; Americas 30.2%; Ashkenazi 38.5%; Finnish 38.6%; Middle Eastern 34.6%; Amish 45.5%.
Estimated GC genotype frequency.
Global 4.9%; European 7.4%; African 0.3%; East Asian 3.2%; South Asian 8.3%; Americas 3.4%; Ashkenazi 6.8%; Finnish 6.8%; Middle Eastern 5.0%; Amish 12.2%.
Estimated CC genotype frequency.
Showing effects for G/G genotype
Cardiovascular & Metabolic
Heart Disease
Cardiomyopathy. Evidence: 7/10. Source: PMID 33495597. Increased Risk.
Heart Rhythm & Conduction
Atrial Fibrillation. Evidence: 7/10. Source: PMID 40645996. Increased Risk.
QT Interval. Evidence: 10/10. Source: PMID 19305408. Typical QT.
Pacemaker Requirement. Evidence: 7/10. Source: PMID 39024449. Increased Risk.
Showing effects for C/C genotype
Cardiomyopathy. Evidence: 7/10. Source: PMID 33495597. Lower Risk.
Atrial Fibrillation. Evidence: 7/10. Source: PMID 40645996. Lower Risk.
QT Interval. Evidence: 10/10. Source: PMID 19305408. ~3.3ms Longer QT.
Pacemaker Requirement. Evidence: 7/10. Source: PMID 39024449. Lower Risk.
Showing effects for G/C genotype
Cardiomyopathy. Evidence: 7/10. Source: PMID 33495597. Typical Risk.
Atrial Fibrillation. Evidence: 7/10. Source: PMID 40645996. Typical Risk.
Pacemaker Requirement. Evidence: 7/10. Source: PMID 39024449. Typical Risk.
What this genotype means for the people who carry it
Sample genotype: GG (Homozygous)
Cardiac muscle structure and electrical stability are closely linked to the RNF207 protein. Carrying two copies of the common G allele maintains a standard QT interval, meaning the heart's ventricles recharge at a typical speed [1]. However, this genetic profile is associated with a significantly higher risk of developing hypertrophic cardiomyopathy, a condition characterized by thickening of the heart muscle [2]. Furthermore, large-scale genetic studies link this genotype to an increased incidence of atrial fibrillation and a higher likelihood of requiring a cardiac pacemaker over time [3].
Elevated risk of hypertrophic cardiomyopathy; Increased likelihood of atrial fibrillation; Higher probability of requiring a pacemaker.
Sample genotype: CC (Homozygous)
Slightly prolonged cardiac repolarization paired with a lower risk of structural heart disease is characteristic of this genotype. Carrying two copies of the C allele increases the QT interval by approximately 3.3 milliseconds, representing a very minor delay in the heart's electrical recovery phase [1]. While extreme QT prolongation can be a risk factor for arrhythmias, this small increase is generally benign and is offset by major structural benefits. Specifically, this genotype is highly protective against hypertrophic cardiomyopathy and atrial fibrillation, reducing the overall likelihood of these serious cardiac conditions [2].
Significantly lower risk of hypertrophic cardiomyopathy; Reduced risk of atrial fibrillation; Minor, typically benign increase in QT interval duration.
Sample genotype: GC (Heterozygous)
Balanced cardiac repolarization and typical structural susceptibility characterize this heterozygous genotype. Having one copy of each allele results in an intermediate phenotype, maintaining a standard QT interval duration [1]. The presence of one protective C allele helps mitigate the elevated risks of hypertrophic cardiomyopathy and atrial fibrillation that are otherwise associated with the G/G genotype [2]. Consequently, cardiovascular risk remains near the population average, making this a neutral baseline for heart health [3].
Typical QT interval duration; Average baseline risk for cardiomyopathy; Standard risk for atrial fibrillation.
Variants with shared genetic architecture
rs3176326 · CDKN1A Gene · Chr 6 · Cardiac Health Risks
rs1886512 · KLF12 Gene · Chr 13 · Atrial Fibrillation Risk
rs2298632 · TCEA3 Gene · Chr 1 · Heart Rhythm and Lipids
Common variants at ten loci influence QT interval duration in the QTGEN Study.
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
Content updated August 2026.
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