What you carry at this position in your DNA and what research says about it.
Cholesterol and Triglycerides: 10/10 evidence, 23 publications.
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Sample genotype (not yours): C/C
Favorable Cholesterol and Triglyceride Levels
Favorable levels of beneficial HDL cholesterol and lower triglycerides characterize this genetic profile. This combination supports a healthier cardiovascular profile.
What this genotype means: Higher HDL cholesterol levels; Lower triglyceride levels; Favorable triglyceride-to-HDL ratio.
Sample genotype (not yours): C/T
Slightly Unfavorable Cholesterol and Triglyceride Levels
Slightly lower HDL cholesterol and mildly elevated triglycerides are associated with this genetic profile. This pattern can slightly increase the risk of an unfavorable lipid profile.
What this genotype means: Slightly lower HDL cholesterol; Mildly elevated triglycerides; Slightly higher triglyceride-to-HDL ratio.
Sample genotype (not yours): T/T
Less Favorable Cholesterol and Triglyceride Levels
Lower HDL cholesterol and higher triglycerides are associated with this genetic profile. This combination is linked to a less optimal cardiovascular lipid profile.
What this genotype means: Lower HDL cholesterol levels; Higher triglyceride levels; Elevated triglyceride-to-HDL ratio.
Gene function and biological role
Gene Function: The CD300LG gene encodes a type I cell surface glycoprotein, also known as nepmucin, which is primarily expressed in vascular endothelial cells [1]. It contains an immunoglobulin V-like domain that plays a key role in lymphocyte binding and transmigration [1]. While members of the CD300 family are known to interact with lipids, CD300LG specifically helps regulate the transport and clearance of circulating lipids [1]. Research indicates that variations in this gene can significantly alter blood lipid profiles, including HDL and triglyceride levels [2].
Variant Impact: A missense mutation in the CD300LG gene changes the amino acid at position 82 from arginine to cysteine (p.Arg82Cys). This amino acid substitution occurs within the critical immunoglobulin domain of the protein, which is essential for its binding functions [3]. The alteration is thought to impact how the protein interacts with lipids and vascular cells, thereby modifying circulating lipid concentrations [3]. Large-scale genomic studies have robustly linked this specific variant to variations in HDL cholesterol, triglycerides, and other metabolic biomarkers [4].
Key Insight: This variant directly alters the structure of a protein on blood vessel walls, changing how the body processes fats. The rare T allele is linked to a less favorable lipid profile, including lower good HDL cholesterol and higher triglycerides.
Location: CD300LG. Chromosome 17 · 17q21.31 · 43.8 Mb
Estimated prevalence by population
Global 96.0%; European 93.9%; African 98.9%; East Asian 99.9%; South Asian 95.6%; Americas 96.7%; Ashkenazi 97.9%; Finnish 94.1%; Middle Eastern 99.3%; Amish 98.2%.
Estimated CC genotype frequency.
Global 3.9%; European 6.0%; African 1.1%; East Asian 0.1%; South Asian 4.3%; Americas 3.3%; Ashkenazi 2.1%; Finnish 5.8%; Middle Eastern 0.7%; Amish 1.7%.
Estimated CT genotype frequency.
Global 0.1%; European 0.1%; African < 0.1%; East Asian < 0.1%; South Asian < 0.1%; Americas < 0.1%; Ashkenazi < 0.1%; Finnish 0.1%; Middle Eastern < 0.1%; Amish < 0.1%.
Estimated TT genotype frequency.
Showing effects for C/C genotype
Cardiovascular & Metabolic
Lipids & Cholesterol
HDL Cholesterol. Evidence: 10/10. Source: PMID 30275531. Higher HDL.
Triglycerides. Evidence: 10/10. Source: PMID 30275531. Lower Triglycerides.
Triglyceride to HDL Ratio. Evidence: 10/10. Source: PMID 38200128. Lower Ratio.
Nutrition & Metabolism
Macronutrient Metabolism
Docosahexaenoic Acid. Evidence: 10/10. Source: PMID 35213538. Higher DHA.
Showing effects for C/T genotype
HDL Cholesterol. Evidence: 10/10. Source: PMID 30275531. Slightly Lower HDL.
Triglycerides. Evidence: 10/10. Source: PMID 30275531. Slightly Higher TG.
Triglyceride to HDL Ratio. Evidence: 10/10. Source: PMID 38200128. Slightly Higher Ratio.
Docosahexaenoic Acid. Evidence: 10/10. Source: PMID 35213538. Slightly Lower DHA.
Showing effects for T/T genotype
HDL Cholesterol. Evidence: 10/10. Source: PMID 30275531. Lower HDL.
Triglycerides. Evidence: 10/10. Source: PMID 30275531. Higher Triglycerides.
Triglyceride to HDL Ratio. Evidence: 10/10. Source: PMID 38200128. Higher Ratio.
Docosahexaenoic Acid. Evidence: 10/10. Source: PMID 35213538. Lower DHA.
What this genotype means for the people who carry it
Sample genotype: CC (Homozygous)
The C allele represents the most common genetic profile globally. Large-scale genome-wide association studies have consistently linked this genotype to a highly favorable blood lipid profile, characterized by higher levels of high-density lipoprotein (HDL) cholesterol [1]. Additionally, individuals with this genotype tend to have lower circulating triglycerides and a healthier triglyceride-to-HDL ratio [2]. These lipid patterns are generally associated with better cardiovascular health and a lower risk of metabolic complications [1]. The C allele also correlates with higher levels of beneficial polyunsaturated fatty acids, such as docosahexaenoic acid (DHA), which play protective roles in the body [3]. Overall, this genetic makeup represents a robust baseline for lipid metabolism.
Higher HDL cholesterol levels; Lower triglyceride levels; Favorable triglyceride-to-HDL ratio; Higher circulating DHA levels.
Sample genotype: CT (Heterozygous)
A single copy of the T allele (Cys82) alters the structure of the CD300LG protein, which is expressed in blood vessel walls. This structural change is associated with a mild shift in how the body processes circulating fats. Studies show that individuals with this heterozygous genotype tend to have slightly lower levels of beneficial HDL cholesterol compared to those with the C/C genotype [1]. Simultaneously, they often exhibit mildly elevated triglyceride levels and a higher triglyceride-to-HDL ratio [2]. There is also a slight reduction in circulating polyunsaturated fatty acids, including docosahexaenoic acid (DHA) [3]. While these changes are typically modest, they represent a slightly less optimal lipid profile that may warrant attention to diet and lifestyle.
Slightly lower HDL cholesterol; Mildly elevated triglycerides; Slightly higher triglyceride-to-HDL ratio; Slightly lower DHA levels.
Sample genotype: TT (Homozygous)
Two copies of the T allele represent a relatively rare genetic profile that significantly impacts CD300LG protein function. This genotype is strongly linked to a less favorable blood lipid profile, characterized by lower levels of protective HDL cholesterol [1]. Concurrently, individuals with this genotype tend to have higher circulating triglycerides and an elevated triglyceride-to-HDL ratio [2]. These lipid patterns are well-documented markers of increased cardiovascular risk and insulin resistance [2]. Furthermore, this genotype is associated with lower levels of beneficial polyunsaturated fatty acids, such as docosahexaenoic acid (DHA), and other key phospholipids [3]. Maintaining a heart-healthy diet and regular exercise can help manage these genetically influenced lipid levels.
Lower HDL cholesterol levels; Higher triglyceride levels; Elevated triglyceride-to-HDL ratio; Lower circulating DHA levels.
Variants with shared genetic architecture
rs116843064 · ANGPTL4 Gene · Chr 19 · Heart Disease Risk
rs12678919 · LPL Gene · Chr 8 · Cholesterol and Lipids
rs13702 · LPL Gene · Chr 8 · Blood Triglyceride Levels
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
Genome-wide characterization of circulating metabolic biomarkers.
Whole genome sequence analysis of blood lipid levels in >66,000 individuals.
Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.
Content updated August 2026.
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