What you carry at this position in your DNA and what research says about it.
Systemic Inflammation: 10/10 evidence, 32 publications.
You're viewing every possible genotype for this variant.
None of these is your result. Use the genotype toggle to compare them, then sign up and upload your DNA to see which one is yours.
Sample genotype (not yours): A/A
Typical Inflammation and Slightly Higher Liver Markers
Baseline inflammatory markers tend to be slightly lower, while liver enzymes and cholesterol may be slightly higher. These minor variations generally remain within the normal physiological range.
What this genotype means: Slightly lower baseline C-reactive protein; Slightly higher baseline liver enzymes; Slightly higher total cholesterol.
Sample genotype (not yours): A/G
Typical Inflammatory and Metabolic Profile
Balanced genetic influences result in typical baseline levels of both inflammatory markers and liver enzymes. This intermediate profile represents the most common physiological baseline.
What this genotype means: Typical baseline inflammatory markers; Typical baseline liver enzymes; Typical baseline cholesterol levels.
Sample genotype (not yours): G/G
Slightly Higher Inflammatory Markers and Typical Liver Profile
Baseline systemic inflammatory markers tend to be slightly higher, while liver enzymes and cholesterol lean slightly lower. These minor variations are typical and generally stay within healthy limits.
What this genotype means: Slightly higher baseline C-reactive protein; Slightly lower baseline liver enzymes; Slightly lower total cholesterol.
Gene function and biological role
Gene Function: The IL1F10 gene encodes interleukin 1 family member 10, a cytokine that participates in the regulation of inflammatory and immune responses. Located within a dense cluster of interleukin-1 genes on chromosome 2, it works in close coordination with neighboring genes like IL1RN, which encodes the interleukin-1 receptor antagonist [1]. This family of proteins plays a critical role in initiating and resolving the body's response to injury and infection [2]. Genetic variation in this region is frequently associated with altered baseline levels of systemic inflammatory biomarkers [3].
Variant Impact: The rs6734238 variant is an intergenic genetic marker located near the IL1F10 and IL1RN genes on chromosome 2. This genetic change acts as a quantitative trait locus, influencing the baseline expression of cytokines and downstream inflammatory proteins [4]. The G allele is consistently linked to higher circulating levels of systemic inflammatory markers, including C-reactive protein and fibrinogen [5]. Conversely, the A allele is associated with higher levels of liver enzymes and total cholesterol [6].
Key Insight: This variant acts as a genetic pivot point, where one allele slightly increases systemic inflammatory markers while the other allele slightly increases metabolic and liver markers.
Location: IL1F10. Chromosome 2 · 2q14.1 · 113.1 Mb
Estimated prevalence by population
Global 37.7%; European 36.0%; African 30.5%; East Asian 86.8%; South Asian 43.2%; Americas 41.9%; Ashkenazi 35.1%; Finnish 48.2%; Middle Eastern 25.0%; Amish 23.8%.
Estimated AA genotype frequency.
Global 46.5%; European 48.0%; African 49.5%; East Asian 12.7%; South Asian 45.1%; Americas 45.7%; Ashkenazi 48.3%; Finnish 42.5%; Middle Eastern 50.0%; Amish 50.0%.
Estimated AG genotype frequency.
Global 15.7%; European 16.0%; African 20.1%; East Asian 0.5%; South Asian 11.8%; Americas 12.4%; Ashkenazi 16.6%; Finnish 9.4%; Middle Eastern 25.0%; Amish 26.2%.
Estimated GG genotype frequency.
Showing effects for A/A genotype
Immunity & Inflammation
Inflammatory & Circulating Protein Markers
C-Reactive Protein. Evidence: 10/10. Source: PMID 21300955. Slightly Lower.
IL-1 Receptor Antagonist. Evidence: 8/10. Source: PMID 22205395. Slightly Higher.
Cardiovascular & Metabolic
Blood Cell & Iron Traits
White Blood Cell Count. Evidence: 10/10. Source: PMID 25096241. Slightly Lower.
Lipids & Cholesterol
Total Cholesterol. Evidence: 8/10. Source: PMID 27286809. Slightly Higher.
Coagulation & Clotting
Fibrinogen Levels. Evidence: 8/10. Source: PMID 23969696. Slightly Lower.
Organ Systems
Liver Function & Disease
ALT Liver Enzyme. Evidence: 9/10. Source: PMID 34315874. Slightly Higher.
Showing effects for A/G genotype
C-Reactive Protein. Evidence: 10/10. Source: PMID 21300955. Typical.
IL-1 Receptor Antagonist. Evidence: 8/10. Source: PMID 22205395. Typical.
White Blood Cell Count. Evidence: 10/10. Source: PMID 25096241. Typical.
Total Cholesterol. Evidence: 8/10. Source: PMID 27286809. Typical.
Fibrinogen Levels. Evidence: 8/10. Source: PMID 23969696. Typical.
ALT Liver Enzyme. Evidence: 9/10. Source: PMID 34315874. Typical.
Showing effects for G/G genotype
C-Reactive Protein. Evidence: 10/10. Source: PMID 21300955. Slightly Higher.
IL-1 Receptor Antagonist. Evidence: 8/10. Source: PMID 22205395. Slightly Lower.
White Blood Cell Count. Evidence: 10/10. Source: PMID 25096241. Slightly Higher.
Total Cholesterol. Evidence: 8/10. Source: PMID 27286809. Slightly Lower.
Fibrinogen Levels. Evidence: 8/10. Source: PMID 23969696. Slightly Higher.
ALT Liver Enzyme. Evidence: 9/10. Source: PMID 34315874. Slightly Lower.
What this genotype means for the people who carry it
Sample genotype: AA (Homozygous)
Baseline levels of systemic inflammatory markers like C-reactive protein and fibrinogen tend to be slightly lower [1]. This is accompanied by a higher level of interleukin-1 receptor antagonist, which helps suppress inflammatory signaling [2]. However, liver enzymes such as alanine aminotransferase and aspartate aminotransferase show a slight tendency to be higher [3]. Total cholesterol levels also lean slightly higher compared to other genotypes [4]. These subtle shifts represent normal physiological variation rather than a disease state. Maintaining a balanced diet and regular exercise supports overall metabolic and liver health.
Slightly lower baseline C-reactive protein; Slightly higher baseline liver enzymes; Slightly higher total cholesterol.
Sample genotype: AG (Heterozygous)
Circulating levels of C-reactive protein, white blood cells, and fibrinogen are maintained at typical baseline levels [1]. Similarly, metabolic markers such as total cholesterol and liver enzymes remain within standard physiological ranges [2]. Having one copy of each allele balances the subtle genetic influences on both the immune and metabolic systems [3]. This intermediate profile is highly common across most global populations. Standard healthy lifestyle choices are sufficient to maintain optimal cardiovascular and metabolic wellness. No specific dietary or medical adjustments are indicated based on this genetic marker.
Typical baseline inflammatory markers; Typical baseline liver enzymes; Typical baseline cholesterol levels.
Sample genotype: GG (Homozygous)
Baseline levels of systemic inflammatory markers, including C-reactive protein and fibrinogen, tend to be slightly higher [1]. White blood cell and neutrophil counts also show a minor upward trend within the normal range [2]. Conversely, liver enzymes like alanine aminotransferase and aspartate aminotransferase tend to be slightly lower [3]. Total cholesterol levels also lean slightly lower compared to other genotypes [4]. These subtle differences represent normal physiological diversity rather than active disease. Supporting cardiovascular health through an anti-inflammatory diet and regular physical activity is a great way to maintain wellness.
Slightly higher baseline C-reactive protein; Slightly lower baseline liver enzymes; Slightly lower total cholesterol.
Variants with shared genetic architecture
rs340005 · RORA Gene · Chr 15 · Inflammation and Liver Health
rs1183910 · HNF1A Gene · Chr 12 · Baseline Inflammation
rs445 · CDK6 Gene · Chr 7 · Immune Cell Levels
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
The Polygenic and Monogenic Basis of Blood Traits and Diseases.
Content updated August 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com