What you carry at this position in your DNA and what research says about it.
Weight and Diet Response: 8/10 evidence, 15 publications.
You're viewing every possible genotype for this variant.
None of these is your result. Use the genotype toggle to compare them, then sign up and upload your DNA to see which one is yours.
Sample genotype (not yours): C/C
Typical Weight and Metabolism Baseline
A standard metabolic profile is expected with this genotype. Weight management and cholesterol levels typically follow general population averages. Standard dietary guidelines remain highly effective for maintaining health.
What this genotype means: Typical baseline BMI; Standard response to low-fat diets.
Sample genotype (not yours): C/T
Slightly Lower BMI and Better Diet Response
A single copy of the protective T allele is linked to a slightly lower body mass index. Weight-loss efforts may be particularly successful when adopting a low-fat, high-fiber diet. Cholesterol levels also tend to be slightly more favorable.
What this genotype means: Slightly lower average BMI; Enhanced weight loss on low-fat diets.
Sample genotype (not yours): T/T
Lower BMI and Enhanced Diet Response
Two copies of the protective T allele are associated with a lower average body mass index. Adopting a low-fat, high-fiber diet can significantly optimize weight loss and insulin sensitivity. Cholesterol levels are also typically lower.
What this genotype means: Lower average BMI; Optimal weight loss on low-fat diets; More favorable cholesterol levels.
Gene function and biological role
Gene Function: Glutaminyl-peptide cyclotransferase-like (QPCTL) is an enzyme that modifies the N-terminus of various proteins and chemokines [1]. It is highly expressed in multiple tissues and plays a key role in post-translational modifications within the Golgi apparatus [1]. Genetic variation near this gene is frequently linked to metabolic traits, including insulin secretion and body mass index [2]. It is located in close proximity to the gastric inhibitory polypeptide receptor (GIPR) gene, which regulates insulin release in response to food intake [2]. Consequently, variations in this region often influence how the body processes nutrients and manages energy storage [2].
Variant Impact: The rs2287019 variant is an intronic change located within the QPCTL gene, situated close to the GIPR locus. This genetic variation is strongly associated with differences in body mass index and body fat distribution [3]. It also influences lipid metabolism, affecting circulating levels of total and LDL cholesterol [4]. Furthermore, clinical trials show that this variant alters how weight-loss diets modify insulin resistance and fasting glucose [5]. The major C allele is linked to higher baseline weight, whereas the minor T allele is associated with metabolic advantages [3] [5].
Key Insight: The T allele enhances weight loss and glucose control specifically when following a low-fat, high-carbohydrate diet.
Location: QPCTL. Chromosome 19 · 19q13.32 · 45.7 Mb
Estimated prevalence by population
Global 69.9%; European 65.2%; African 78.2%; East Asian 66.5%; South Asian 71.5%; Americas 76.1%; Ashkenazi 51.4%; Finnish 64.4%; Middle Eastern 70.0%; Amish 78.1%.
Estimated CC genotype frequency.
Global 27.3%; European 31.1%; African 20.5%; East Asian 30.1%; South Asian 26.1%; Americas 22.3%; Ashkenazi 40.6%; Finnish 31.7%; Middle Eastern 27.3%; Amish 20.5%.
Estimated CT genotype frequency.
Global 2.9%; European 3.7%; African 1.3%; East Asian 3.4%; South Asian 2.4%; Americas 1.6%; Ashkenazi 8.0%; Finnish 3.9%; Middle Eastern 2.7%; Amish 1.4%.
Estimated TT genotype frequency.
Showing effects for C/C genotype
Cardiovascular & Metabolic
Obesity & Body Composition
Body Mass Index. Evidence: 8/10. Source: PMID 20935630. Typical BMI.
Lipids & Cholesterol
Cholesterol Levels. Evidence: 5/10. Source: PMID 35884923. Typical Cholesterol.
Hypertension
Blood Pressure. Evidence: 6/10. Source: PMID 33230300. Typical Pressure.
Nutrition & Metabolism
Macronutrient Metabolism
Diet Response. Evidence: 3/10. Source: PMID 22237064. Typical Response.
Showing effects for C/T genotype
Body Mass Index. Evidence: 8/10. Source: PMID 20935630. Slightly Lower BMI.
Cholesterol Levels. Evidence: 5/10. Source: PMID 35884923. Slightly Lower LDL.
Diet Response. Evidence: 3/10. Source: PMID 22237064. Improved Response.
Showing effects for T/T genotype
Body Mass Index. Evidence: 8/10. Source: PMID 20935630. Lower BMI.
Cholesterol Levels. Evidence: 5/10. Source: PMID 35884923. Lower LDL.
Blood Pressure. Evidence: 6/10. Source: PMID 33230300. Slightly Higher BP.
Diet Response. Evidence: 3/10. Source: PMID 22237064. Highly Responsive.
What this genotype means for the people who carry it
Sample genotype: CC (Homozygous)
Having two copies of the common C allele is associated with typical baseline body mass index and body fat distribution [1]. Research indicates that individuals with this profile do not experience the enhanced weight-loss response to low-fat diets seen in T allele carriers [2]. Cholesterol levels, including LDL and total cholesterol, generally align with standard population averages [3]. Blood pressure regulation also remains within the typical range, without the slight elevations associated with the minor variant [4]. Standard healthy eating patterns and regular physical activity are the most effective strategies for long-term weight maintenance. Focus on a balanced diet rich in whole foods to support cardiovascular and metabolic health.
Typical baseline BMI; Standard response to low-fat diets.
Sample genotype: CT (Heterozygous)
Carrying one copy of the T allele is associated with a modest reduction in average body mass index and waist circumference [1]. Clinical studies suggest that weight-loss interventions are particularly effective for this genotype when focusing on low-fat, high-carbohydrate, and high-fiber diets [2]. This dietary approach has been shown to yield greater improvements in fasting glucose and insulin sensitivity [2]. Additionally, this profile is linked to slightly lower levels of LDL and total cholesterol compared to the common genotype [3]. Although a minor increase in systolic blood pressure has been noted in genetic studies, the actual clinical impact is negligible [4]. Emphasizing dietary fiber and reducing saturated fat intake can maximize these metabolic benefits. Regular cardiovascular exercise further supports healthy weight management.
Slightly lower average BMI; Enhanced weight loss on low-fat diets.
Sample genotype: TT (Homozygous)
Possessing two copies of the T allele is linked to the lowest average body mass index and waist-to-hip ratio within this genetic group [1]. Clinical trials demonstrate that individuals with this genotype experience highly pronounced weight-loss benefits when following a low-fat, high-fiber diet [2]. This specific dietary pattern also drives substantial improvements in glucose homeostasis and insulin resistance [2]. Favorable lipid profiles, including lower LDL and total cholesterol, are commonly observed [3]. While a very slight increase in systolic blood pressure is genetically associated with this genotype, the effect size is extremely small and unlikely to be clinically meaningful [4]. Prioritizing a plant-forward, low-fat diet rich in complex carbohydrates can fully unlock these genetic metabolic advantages. Combining this nutrition plan with consistent physical activity provides optimal support for long-term health.
Lower average BMI; Optimal weight loss on low-fat diets; More favorable cholesterol levels.
Variants with shared genetic architecture
rs10182181 · ADCY3 Gene · Chr 2 · Weight and Diet Response
rs10968576 · LINGO2 Gene · Chr 9 · Weight and Metabolic Risk
rs2112347 · POC5 Gene · Chr 5 · Obesity and Body Fat
New role of fat-free mass in cancer risk linked with genetic predisposition.
New genetic loci link adipose and insulin biology to body fat distribution.
Genetic studies of body mass index yield new insights for obesity biology.
Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease.
Content updated August 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com