What you carry at this position in your DNA and what research says about it.
Gout and Cholesterol: 8/10 evidence, 32 publications.
You're viewing every possible genotype for this variant.
None of these is your result. Use the genotype toggle to compare them, then sign up and upload your DNA to see which one is yours.
Sample genotype (not yours): G/G
Higher Cholesterol but Better Kidney Function
This genotype is associated with elevated LDL cholesterol levels alongside a lower risk of gout and superior kidney filtration.
What this genotype means: Elevated LDL and total cholesterol levels; Lower risk of uric acid buildup and gout; More efficient kidney filtration rates.
Sample genotype (not yours): A/A
Lower Cholesterol but Higher Gout Risk
This genotype is linked to healthier, lower cholesterol levels but carries an increased risk of gout and reduced kidney filtration.
What this genotype means: Lower LDL and total cholesterol levels; Increased risk of uric acid accumulation and gout; Slightly reduced kidney filtration efficiency.
Sample genotype (not yours): G/A
Typical Cholesterol and Gout Balance
This genotype represents the intermediate baseline, maintaining typical cholesterol levels and standard kidney filtration.
What this genotype means: Typical baseline levels of LDL cholesterol; Standard risk of gout and uric acid accumulation; Average kidney filtration and creatinine clearance.
Gene function and biological role
Gene Function: The LOC105373585 region is a genetic locus situated close to the INHBB gene, which encodes the inhibin beta B chain protein [1]. This protein is a key component of activins and inhibins, which belong to the transforming growth factor-beta superfamily and regulate cell growth and hormone secretion [1]. Genetic variations in this genomic neighborhood are heavily implicated in metabolic processes, particularly the transport and clearance of organic anions [2]. Through these pathways, the region plays a dual role in modulating both circulating lipid levels and renal excretion of metabolic waste products [2].
Variant Impact: The rs17050272 variant is an intronic genetic marker that acts as a major metabolic pivot, influencing how the body balances lipids and renal filtration. The G allele is strongly associated with higher levels of LDL and total cholesterol [3]. Conversely, the A allele is linked to elevated serum urate levels and a higher risk of developing gout [4]. This genetic variation also affects kidney function markers, altering the glomerular filtration rate and creatinine clearance [5]. Consequently, this single genetic change represents a direct physiological trade-off between cardiovascular lipid profiles and renal metabolic efficiency [5].
Key Insight: This variant represents a direct evolutionary trade-off where genotypes that protect against high cholesterol simultaneously increase the risk of gout and reduce kidney filtration efficiency.
Location: INHBB. Chromosome 2 · 2q14.2 · 120.5 Mb
Estimated prevalence by population
Global 46.5%; European 33.7%; African 81.5%; East Asian 28.1%; South Asian 49.0%; Americas 35.1%; Ashkenazi 40.0%; Finnish 20.0%; Middle Eastern 41.3%; Amish 39.5%.
Estimated GG genotype frequency.
Global 39.9%; European 48.7%; African 17.6%; East Asian 49.8%; South Asian 42.0%; Americas 48.3%; Ashkenazi 46.5%; Finnish 49.5%; Middle Eastern 45.9%; Amish 46.7%.
Estimated GA genotype frequency.
Global 13.6%; European 17.6%; African 0.9%; East Asian 22.1%; South Asian 9.0%; Americas 16.6%; Ashkenazi 13.5%; Finnish 30.5%; Middle Eastern 12.8%; Amish 13.8%.
Estimated AA genotype frequency.
Showing effects for G/G genotype
Cardiovascular & Metabolic
Gout & Uric Acid
Gout. Evidence: 8/10. Source: PMID 39024449. Lower Risk.
Lipids & Cholesterol
LDL Cholesterol. Evidence: 10/10. Source: PMID 30275531. Higher LDL.
Organ Systems
Kidney Function & Disease
Kidney Function. Evidence: 8/10. Source: PMID 26831199. Better Filtration.
Liver Function & Disease
GGT Liver Enzyme. Evidence: 8/10. Source: PMID 33972514. Lower GGT Levels.
Showing effects for A/A genotype
Gout. Evidence: 8/10. Source: PMID 39024449. ~1.08x Higher Risk.
LDL Cholesterol. Evidence: 10/10. Source: PMID 30275531. Lower LDL.
Kidney Function. Evidence: 8/10. Source: PMID 26831199. Reduced Filtration.
GGT Liver Enzyme. Evidence: 8/10. Source: PMID 33972514. Higher GGT Levels.
Showing effects for G/A genotype
Gout. Evidence: 8/10. Source: PMID 39024449. Typical Risk.
LDL Cholesterol. Evidence: 10/10. Source: PMID 30275531. Typical LDL.
Kidney Function. Evidence: 8/10. Source: PMID 26831199. Typical Filtration.
GGT Liver Enzyme. Evidence: 8/10. Source: PMID 33972514. Typical GGT Levels.
What this genotype means for the people who carry it
Sample genotype: GG (Homozygous)
Carrying two copies of the G allele places you in a distinct metabolic category characterized by efficient renal clearance but elevated circulating lipids. Large-scale genetic studies show that this genotype is linked to higher levels of LDL and total cholesterol [1]. However, the same biological mechanism provides robust protection against uric acid accumulation, resulting in a significantly lower risk of gout [2]. Kidney function markers are also highly favorable, with studies demonstrating higher estimated glomerular filtration rates and lower serum creatinine levels [3]. This represents a classic physiological trade-off where cardiovascular lipid management is slightly compromised in exchange for superior renal waste excretion [3].
Elevated LDL and total cholesterol levels; Lower risk of uric acid buildup and gout; More efficient kidney filtration rates.
Sample genotype: AA (Homozygous)
Carrying two copies of the A allele optimizes your cardiovascular lipid profile at the expense of renal clearance efficiency. Clinical data associates this genotype with lower circulating levels of LDL and total cholesterol [1]. However, this benefit is offset by a reduced capacity to excrete metabolic waste products, leading to higher serum urate levels and an elevated risk of gout [2]. Kidney function metrics are also less optimal, characterized by lower estimated glomerular filtration rates and higher creatinine levels [3]. Additionally, studies have noted slightly higher levels of the liver enzyme gamma-glutamyl transferase in individuals with this genotype [4].
Lower LDL and total cholesterol levels; Increased risk of uric acid accumulation and gout; Slightly reduced kidney filtration efficiency.
Sample genotype: GA (Heterozygous)
Carrying one G allele and one A allele results in a balanced metabolic profile that mirrors the general population average. Your body manages the trade-off between lipid clearance and renal filtration without leaning heavily in either direction. Studies indicate that your LDL cholesterol and total cholesterol levels are likely within the typical range [1]. Similarly, your risk of developing gout and your overall kidney filtration markers, such as creatinine and blood urea nitrogen, remain at baseline levels [2]. This intermediate state avoids the elevated cholesterol risks of the G/G genotype as well as the increased gout risks of the A/A genotype [3].
Typical baseline levels of LDL cholesterol; Standard risk of gout and uric acid accumulation; Average kidney filtration and creatinine clearance.
Variants with shared genetic architecture
rs10224210 · PRKAG2 Gene · Chr 7 · Kidney Health and Gout
rs963837 · MPPED2 Gene · Chr 11 · Kidney Function and Health
rs2229357 · INHBC Gene · Chr 12 · Gout and Heart Risk
Mapping the proteo-genomic convergence of human diseases.
A genetic map of human metabolism across the allele frequency spectrum.
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
A genome-wide association analysis reveals new pathogenic pathways in gout.
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes.
Content updated August 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com