What you carry at this position in your DNA and what research says about it.
Blood Vessel Health: 6/10 evidence, 56 publications.
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Sample genotype (not yours): A/A
Higher Risk of Blood Vessel Complications
Reduced production of VEGF protein is common with this genetic profile. Lower levels of this growth factor are linked to an increased risk of blood vessel complications and certain infant health conditions.
What this genotype means: Reduced VEGF protein production; Increased risk of hypertensive nephropathy; Altered response to chemotherapy drugs.
Sample genotype (not yours): A/G
A single copy of the A allele is associated with reduced VEGF protein levels. This can elevate the risk of vascular issues and specific developmental complications.
What this genotype means: Moderately reduced VEGF protein production; Increased risk of hypertensive nephropathy; Altered response to sorafenib.
Sample genotype (not yours): G/G
Typical Blood Vessel Health
Two copies of the G allele represent the typical genetic profile for standard VEGF protein production. This is associated with a baseline risk for vascular complications.
What this genotype means: Standard VEGF protein production; Typical baseline vascular risk; Slightly higher HbA1c levels.
Gene function and biological role
Gene Function: Vascular endothelial growth factor A is a crucial protein that stimulates the growth of new blood vessels [1]. It plays a vital role in normal physiological processes such as wound healing, tissue repair, and embryonic development [1]. However, abnormal levels of this protein are also associated with various disease states, including tumor growth and diabetic complications [2]. The activity of this gene is tightly regulated by genetic variations and environmental factors [3].
Variant Impact: The rs1570360 variant is located in the promoter region of the VEGFA gene, often referred to as the -1154 position [1]. This genetic change directly influences how much VEGF protein the body produces [1]. The minor A allele is associated with reduced promoter activity, leading to lower overall levels of VEGF protein [1]. This reduction in blood vessel growth factor can impact tissue recovery and has been linked to various vascular and inflammatory conditions [4].
Key Insight: The rs1570360 variant directly regulates the production of VEGF, a protein essential for blood vessel growth, thereby influencing both cardiovascular risk and response to cancer therapies.
Location: VEGFA. Chromosome 6 · 6p21.1 · 43.8 Mb
Estimated prevalence by population
Global 7.2%; European 10.6%; African 0.6%; East Asian 3.2%; South Asian 8.7%; Americas 4.7%; Ashkenazi 8.9%; Finnish 13.4%; Middle Eastern 9.5%; Amish 25.0%.
Estimated AA genotype frequency.
Global 34.5%; European 44.0%; African 14.7%; East Asian 29.4%; South Asian 41.6%; Americas 34.1%; Ashkenazi 41.9%; Finnish 46.4%; Middle Eastern 42.6%; Amish 50.0%.
Estimated AG genotype frequency.
Global 58.3%; European 45.4%; African 84.7%; East Asian 67.4%; South Asian 49.7%; Americas 61.2%; Ashkenazi 49.2%; Finnish 40.3%; Middle Eastern 47.9%; Amish 25.0%.
Estimated GG genotype frequency.
Showing effects for A/A genotype
Rare Genetic Disorders
Congenital Malformations
Sudden Infant Death. Evidence: 3/10. Source: PMID 16916659. ~3x Higher Risk.
Organ Systems
Kidney Function & Disease
Hypertensive Kidney Disease. Evidence: 3/10. Source: PMID 21080079. Increased Risk.
Cardiovascular & Metabolic
Diabetes & Glycemic Traits
Blood Glucose. Evidence: 6/10. Source: PMID 39789286. Slightly Lower.
Blood Cell & Iron Traits
Red Blood Cell Count. Evidence: 6/10. Source: PMID 40436827. Slightly Higher.
Endocrine & Reproductive
Hormone Levels & Endocrine Regulation
SHBG Levels. Evidence: 6/10. Source: PMID 32042192. Slightly Higher.
Pharmacogenomics
Chemotherapy Response
Cancer Drug Response. Evidence: 5/10. Source: PMID 25111199. Altered Response.
Showing effects for A/G genotype
Blood Glucose. Evidence: 6/10. Source: PMID 39789286. Typical.
Red Blood Cell Count. Evidence: 6/10. Source: PMID 40436827. Typical.
SHBG Levels. Evidence: 6/10. Source: PMID 32042192. Typical.
Showing effects for G/G genotype
Sudden Infant Death. Evidence: 3/10. Source: PMID 16916659. Typical Risk.
Hypertensive Kidney Disease. Evidence: 3/10. Source: PMID 21080079. Typical Risk.
Blood Glucose. Evidence: 6/10. Source: PMID 39789286. Slightly Higher.
Red Blood Cell Count. Evidence: 6/10. Source: PMID 40436827. Slightly Lower.
SHBG Levels. Evidence: 6/10. Source: PMID 32042192. Slightly Lower.
What this genotype means for the people who carry it
Sample genotype: AA (Homozygous)
Lower levels of vascular endothelial growth factor can impair the body's ability to repair and maintain healthy blood vessels. Research indicates that this genetic profile is associated with a significantly higher risk of sudden infant death syndrome [1]. It has also been linked to severe ischemic complications in giant cell arteritis and hypertensive nephropathy [2]. Additionally, this variant may influence how the body responds to certain cancer therapies, such as docetaxel and sorafenib [3]. Maintaining cardiovascular health through standard lifestyle measures is particularly important for those with this profile.
Reduced VEGF protein production; Increased risk of hypertensive nephropathy; Altered response to chemotherapy drugs.
Sample genotype: AG (Heterozygous)
Possessing one copy of the A allele leads to a moderate reduction in the expression of VEGF protein. This reduction is associated with an increased susceptibility to sudden infant death syndrome [1]. It is also linked to a higher risk of hypertensive nephropathy and other vascular complications [2]. Furthermore, individuals with this profile may experience altered survival outcomes when treated with specific chemotherapies like sorafenib [3]. Monitoring blood pressure and cardiovascular health is a prudent approach to managing these potential risks.
Moderately reduced VEGF protein production; Increased risk of hypertensive nephropathy; Altered response to sorafenib.
Sample genotype: GG (Homozygous)
Standard levels of vascular endothelial growth factor help maintain normal blood vessel growth and tissue repair. This common genetic profile is associated with a typical baseline risk for sudden infant death syndrome [1]. It also carries a standard risk level for inflammatory vascular conditions like giant cell arteritis [2]. However, this genotype is associated with slightly higher HbA1c levels, which is a marker for blood sugar [3]. In oncology settings, this profile has been linked to poorer responses to bevacizumab but better responses to cetuximab [4].
Standard VEGF protein production; Typical baseline vascular risk; Slightly higher HbA1c levels.
Variants with shared genetic architecture
rs833061 · VEGFA Gene · Chr 6 · Blood and Joint Health
rs699947 · VEGFA Gene · Chr 6 · Thyroid Cancer Risk
rs2010963 · VEGFA Gene · Chr 6 · Heart and Eye Health
Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.
Association of sudden infant death syndrome with VEGF and IL-6 gene polymorphisms.
A scalable variational inference approach for increased mixed-model association power.
Content updated August 2026.
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