What you carry at this position in your DNA and what research says about it.
Vascular Health: 10/10 evidence, 34 publications.
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Sample genotype (not yours): T/T
Higher Migraine and Arterial Dissection Risk
Two copies of the T allele are associated with an increased susceptibility to migraines and structural arterial issues like spontaneous coronary artery dissection. Conversely, this profile is linked to a lower risk of classic coronary artery disease and lower average pulse pressure.
What this genotype means: Increased susceptibility to migraines; Higher risk of spontaneous coronary artery dissection; Lower risk of classic coronary artery disease.
Sample genotype (not yours): C/C
Higher Coronary Artery Disease Risk
Two copies of the C allele are associated with an increased risk of classic coronary artery disease and higher pulse pressure. However, this genotype offers strong protection against migraines, spontaneous coronary artery dissection, and aneurysms.
What this genotype means: Increased risk of coronary artery disease; Lower risk of migraines and headaches; Protection against spontaneous coronary artery dissection.
Sample genotype (not yours): T/C
Typical Vascular Risk Profile
Carrying one T allele and one C allele provides a balanced genetic influence on vascular health. This intermediate profile does not significantly elevate the risk for either structural arterial dissections or classic coronary artery disease.
What this genotype means: Typical risk for migraines; Typical risk for coronary artery disease; Balanced arterial wall integrity.
Gene function and biological role
Gene Function: LRP1 encodes low-density lipoprotein receptor-related protein 1, a large cell-surface receptor widely expressed in vascular smooth muscle cells, hepatocytes, and neurons [1]. It plays a critical role in clearing lipoproteins from the blood, maintaining vascular wall integrity, and regulating cellular migration [1] [2]. In the blood vessels, LRP1 helps control the structure of the extracellular matrix and modulates signaling pathways like TGF-beta [2]. Disruption or altered expression of this receptor can lead to weakened arterial walls or abnormal tissue remodeling [2]. Consequently, genetic variation in this gene is heavily implicated in a broad spectrum of cardiovascular and neurovascular conditions [2].
Variant Impact: Located in the first intron of the LRP1 gene, rs11172113 is a common single nucleotide polymorphism that acts as a transcriptional enhancer [1]. The T allele of this variant is associated with increased expression of the LRP1 gene in vascular tissues [1]. This altered expression level influences the cellular behavior of vascular smooth muscle cells, affecting their proliferation and extracellular matrix deposition [1]. Because of these structural effects on blood vessel walls, this variant acts as a major genetic pivot, shifting susceptibility between different types of vascular diseases [1] [3]. While one allele increases the risk of structural arterial weaknesses like dissections and aneurysms, the other allele elevates the risk of classic atherosclerotic plaque buildup [3].
Key Insight: This variant acts as a genetic see-saw, where protecting against migraines and arterial tears simultaneously increases the risk of classic heart disease.
Location: LRP1. Chromosome 12 · 12q13.3 · 57.1 Mb
Estimated prevalence by population
Global 34.4%; European 35.9%; African 31.8%; East Asian 56.2%; South Asian 37.2%; Americas 23.7%; Ashkenazi 37.6%; Finnish 36.0%; Middle Eastern 45.8%; Amish 40.3%.
Estimated TT genotype frequency.
Global 48.1%; European 48.0%; African 49.2%; East Asian 37.5%; South Asian 47.6%; Americas 50.0%; Ashkenazi 47.4%; Finnish 48.0%; Middle Eastern 43.7%; Amish 46.3%.
Estimated TC genotype frequency.
Global 17.5%; European 16.1%; African 19.0%; East Asian 6.2%; South Asian 15.2%; Americas 26.4%; Ashkenazi 15.0%; Finnish 16.0%; Middle Eastern 10.4%; Amish 13.3%.
Estimated CC genotype frequency.
Showing effects for T/T genotype
Neurology & Mental Health
Headache & Migraine
Migraine. Evidence: 10/10. Source: PMID 21666692. Increased Risk.
Cardiovascular & Metabolic
Vascular Health & Aneurysm
Spontaneous Coronary Artery Dissection. Evidence: 6/10. Source: PMID 32374345. ~1.6x Increased Risk.
Fibromuscular Dysplasia. Evidence: 4/10. Source: PMID 34654805. ~1.3x Increased Risk.
Cervical Artery Dissection. Evidence: 8/10. Source: PMID 25420145. ~1.2x Increased Risk.
Aortic Aneurysm. Evidence: 8/10. Source: PMID 36777996. Increased Risk.
Heart Disease
Coronary Artery Disease. Evidence: 8/10. Source: PMID 29212778. Lower Risk.
Hypertension
Pulse Pressure. Evidence: 8/10. Source: PMID 32632093. Lower.
Obesity & Body Composition
Body Fat Percentage. Evidence: 8/10. Source: PMID 33980691. Lower.
Showing effects for C/C genotype
Migraine. Evidence: 10/10. Source: PMID 21666692. ~0.8x Lower Risk.
Spontaneous Coronary Artery Dissection. Evidence: 6/10. Source: PMID 32374345. Lower Risk.
Fibromuscular Dysplasia. Evidence: 4/10. Source: PMID 34654805. Lower Risk.
Cervical Artery Dissection. Evidence: 8/10. Source: PMID 25420145. Lower Risk.
Aortic Aneurysm. Evidence: 8/10. Source: PMID 36777996. Lower Risk.
Coronary Artery Disease. Evidence: 8/10. Source: PMID 29212778. Increased Risk.
Pulse Pressure. Evidence: 8/10. Source: PMID 32632093. Higher.
Body Fat Percentage. Evidence: 8/10. Source: PMID 33980691. Higher.
Showing effects for T/C genotype
Migraine. Evidence: 10/10. Source: PMID 21666692. Typical.
Spontaneous Coronary Artery Dissection. Evidence: 6/10. Source: PMID 32374345. Typical.
Fibromuscular Dysplasia. Evidence: 4/10. Source: PMID 34654805. Typical.
Cervical Artery Dissection. Evidence: 8/10. Source: PMID 25420145. Typical.
Aortic Aneurysm. Evidence: 8/10. Source: PMID 36777996. Typical.
Coronary Artery Disease. Evidence: 8/10. Source: PMID 29212778. Typical.
Pulse Pressure. Evidence: 8/10. Source: PMID 32632093. Typical.
Body Fat Percentage. Evidence: 8/10. Source: PMID 33980691. Typical.
What this genotype means for the people who carry it
Sample genotype: TT (Homozygous)
Having two copies of the T allele significantly increases the risk of several structural vascular conditions. Large-scale genetic studies show a strong association with spontaneous coronary artery dissection, a rare but serious tear in the heart's blood vessels [1]. It also elevates the risk of cervical artery dissection, fibromuscular dysplasia, and abdominal aortic aneurysms [2] [3]. Furthermore, this genotype is a well-established risk factor for common migraines and general headaches [4]. On the positive side, the T allele appears protective against classic coronary artery disease and plaque buildup [5]. It is also associated with lower average pulse pressure and slightly lower body fat percentage [6].
Increased susceptibility to migraines; Higher risk of spontaneous coronary artery dissection; Lower risk of classic coronary artery disease.
Sample genotype: CC (Homozygous)
Carrying two copies of the C allele shifts the vascular risk profile toward classic atherosclerotic conditions. Large-scale genome-wide association studies link this genotype to an increased risk of coronary artery disease and myocardial infarction [1]. It is also associated with higher average pulse pressure and a slightly higher body fat percentage [2]. Conversely, the C allele is highly protective against structural arterial weaknesses. This genotype is associated with a significantly lower risk of spontaneous coronary artery dissection and cervical artery dissection [3] [4]. It also reduces the likelihood of developing fibromuscular dysplasia and abdominal aortic aneurysms [5]. Finally, C/C carriers enjoy a lower risk of experiencing migraines and chronic headaches [6].
Increased risk of coronary artery disease; Lower risk of migraines and headaches; Protection against spontaneous coronary artery dissection.
Sample genotype: TC (Heterozygous)
Carrying one copy of each allele results in a balanced or typical risk profile across multiple vascular traits. The presence of one T allele slightly increases the risk of migraines and structural arterial conditions compared to the C/C genotype, but to a lesser degree than the T/T genotype [1]. At the same time, the single C allele moderately increases the risk of classic coronary artery disease and pulse pressure compared to T/T [2]. This heterozygous state represents the most common genetic baseline in many populations, where opposing vascular risks largely offset each other. It does not warrant any specific clinical concern for either extreme of the LRP1-associated disease spectrum.
Typical risk for migraines; Typical risk for coronary artery disease; Balanced arterial wall integrity.
Variants with shared genetic architecture
rs1799986 · LRP1 Gene · Chr 12 · Cardiovascular and Diet Risk
rs28451064 · KCNE2 Gene · Chr 21 · Arterial Health and SCAD Risk
rs1800470 · TGFB1 Gene · Chr 19 · Cardiovascular Health
A cross-population atlas of genetic associations for 220 human phenotypes.
Content updated August 2026.
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