What you carry at this position in your DNA and what research says about it.
Platelets and Triglycerides: 8/10 evidence, 24 publications.
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Sample genotype (not yours): A/A
Higher Triglycerides and Lower Platelet Count
This genotype is associated with slightly higher blood triglyceride levels and a lower concentration of circulating platelets. It may also elevate the risk of developing thrombocytopenia.
What this genotype means: Higher serum triglycerides; Lower platelet count; Increased risk of thrombocytopenia.
Sample genotype (not yours): A/T
Typical Platelet and Triglyceride Levels
This genotype represents an intermediate genetic profile, resulting in typical platelet counts and average triglyceride levels.
What this genotype means: Typical platelet count; Average triglyceride levels.
Sample genotype (not yours): T/T
Lower Triglycerides and Higher Platelet Count
This genotype is linked to lower blood triglyceride levels and a higher, healthy concentration of circulating platelets.
What this genotype means: Lower serum triglycerides; Higher platelet count; Reduced risk of thrombocytopenia.
Gene function and biological role
Gene Function: The JMJD1C gene encodes a member of the jumonji domain-containing family of histone demethylases, which play a key role in epigenetic regulation. This enzyme is involved in chromatin remodeling and gene expression pathways that are highly active in blood-forming stem cells. It is particularly crucial for megakaryopoiesis, the biological process that governs platelet formation and development [1]. Additionally, JMJD1C has been shown to influence metabolic pathways, specifically regulating lipid metabolism and circulating triglyceride levels [2].
Variant Impact: The rs10761731 variant is an intronic single nucleotide polymorphism located within the JMJD1C gene on chromosome 10. This genetic variation acts as a quantitative trait locus that modulates the expression of the gene, thereby influencing downstream blood cell traits and lipid levels [3]. The T allele is associated with higher circulating platelet counts and lower serum triglyceride levels [3]. Conversely, the A allele is linked to lower platelet counts and higher triglycerides [4].
Key Insight: This single genetic variant acts as a dual regulator, simultaneously influencing both the cellular clotting components of your blood and your metabolic lipid profile.
Location: JMJD1C. Chromosome 10 · 10q21.3 · 63.3 Mb
Estimated prevalence by population
Global 38.3%; European 32.9%; African 46.7%; East Asian 44.9%; South Asian 24.8%; Americas 46.6%; Ashkenazi 19.4%; Finnish 38.2%; Middle Eastern 34.3%; Amish 26.7%.
Estimated AA genotype frequency.
Global 46.6%; European 48.9%; African 43.3%; East Asian 44.2%; South Asian 50.0%; Americas 43.3%; Ashkenazi 49.3%; Finnish 47.2%; Middle Eastern 48.5%; Amish 49.9%.
Estimated AT genotype frequency.
Global 15.2%; European 18.2%; African 10.0%; East Asian 10.9%; South Asian 25.2%; Americas 10.1%; Ashkenazi 31.3%; Finnish 14.6%; Middle Eastern 17.2%; Amish 23.4%.
Estimated TT genotype frequency.
Showing effects for A/A genotype
Cardiovascular & Metabolic
Blood Cell & Iron Traits
Platelet Count. Evidence: 10/10. Source: PMID 22139419. Lower.
Lipids & Cholesterol
Triglycerides. Evidence: 8/10. Source: PMID 20686565.
Coagulation & Clotting
Platelet Aggregation. Evidence: 10/10. Source: PMID 29185836. Lower.
Rare Genetic Disorders
Bleeding & Coagulation Disorders
Thrombocytopenia. Evidence: 8/10. Source: PMID 39024449. Increased Risk.
Immunity & Inflammation
Inflammatory & Circulating Protein Markers
Interleukin-12 Levels. Evidence: 4/10. Source: PMID 27989323. Lower.
VEGF-A Levels. Evidence: 4/10. Source: PMID 27989323. Lower.
Showing effects for A/T genotype
Platelet Count. Evidence: 10/10. Source: PMID 22139419. Typical.
Triglycerides. Evidence: 8/10. Source: PMID 20686565. Typical.
Platelet Aggregation. Evidence: 10/10. Source: PMID 29185836. Typical.
Thrombocytopenia. Evidence: 8/10. Source: PMID 39024449. Typical Risk.
Interleukin-12 Levels. Evidence: 4/10. Source: PMID 27989323. Typical.
VEGF-A Levels. Evidence: 4/10. Source: PMID 27989323. Typical.
Showing effects for T/T genotype
Platelet Count. Evidence: 10/10. Source: PMID 22139419. Higher.
Platelet Aggregation. Evidence: 10/10. Source: PMID 29185836. Higher.
Thrombocytopenia. Evidence: 8/10. Source: PMID 39024449. Reduced Risk.
Interleukin-12 Levels. Evidence: 4/10. Source: PMID 27989323. Higher.
VEGF-A Levels. Evidence: 4/10. Source: PMID 27989323. Higher.
What this genotype means for the people who carry it
Sample genotype: AA (Homozygous)
Carrying two copies of the A allele at this locus is linked to metabolic and blood cell profiles that lean toward higher cardiovascular and bleeding risks. At the same time, this genotype is associated with lower overall platelet counts, which can elevate the risk of thrombocytopenia [2]. Individuals with this profile may also exhibit lower platelet aggregation and reduced levels of certain inflammatory signaling proteins like interleukin-12 [3]. While these effects are subtle and represent normal biological variation, maintaining a heart-healthy lifestyle and monitoring lipid panels can help manage overall cardiovascular wellness.
Higher serum triglycerides; Lower platelet count; Increased risk of thrombocytopenia.
Sample genotype: AT (Heterozygous)
Having one copy of each allele provides a balanced genetic influence on both blood cell production and lipid metabolism. Platelet counts and triglyceride levels typically fall within the average range for the general population [1]. This intermediate status means there is no strong genetic predisposition toward either high triglycerides or low platelet counts [2]. Other lifestyle factors, such as diet, exercise, and overall cardiovascular health, will play a much larger role in determining actual blood marker levels. Standard health maintenance and routine blood panels are generally sufficient for monitoring these markers.
Typical platelet count; Average triglyceride levels.
Sample genotype: TT (Homozygous)
Carrying two copies of the T allele is associated with a favorable lipid profile and robust blood cell production. Studies indicate that this genotype is linked to significantly lower serum triglyceride levels, which supports cardiovascular health [1]. Additionally, it is associated with higher platelet counts within the normal range, reducing the likelihood of experiencing thrombocytopenia [2]. The T allele also correlates with increased platelet aggregation and higher levels of vascular endothelial growth factor (VEGF-A) and interleukin-12, which are involved in blood vessel maintenance and immune responses [3]. These combined factors contribute to an overall efficient metabolic and circulatory profile.
Lower serum triglycerides; Higher platelet count; Reduced risk of thrombocytopenia.
Variants with shared genetic architecture
rs10761741 · JMJD1C Gene · Chr 10 · Blood Vessel Growth Factor
rs7896518 · JMJD1C Gene · Chr 10 · HDL Cholesterol Levels
rs1935 · JMJD1C Gene · Chr 10 · Body Fat and Metabolism
New gene functions in megakaryopoiesis and platelet formation.
Biological, clinical and population relevance of 95 loci for blood lipids.
The Polygenic and Monogenic Basis of Blood Traits and Diseases.
Discovery and refinement of loci associated with lipid levels.
A large electronic-health-record-based genome-wide study of serum lipids.
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
Content updated August 2026.
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