What you carry at this position in your DNA and what research says about it.
Psoriasis Risk: 10/10 evidence, 10 publications.
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Sample genotype (not yours): C/C
Typical Psoriasis Risk
Two copies of the common C allele mean typical baseline risk for psoriasis. This genotype does not carry the elevated risk associated with the T variant.
What this genotype means: Typical baseline risk for psoriasis; Standard viral progression rate.
Sample genotype (not yours): C/T
Increased Psoriasis Risk
Carrying one copy of the T allele is linked to a roughly 2.8-fold increase in the risk of developing psoriasis. This genotype also influences how the immune system responds to certain infections.
What this genotype means: ~2.8x increased risk of psoriasis; Slower progression to AIDS if infected with HIV.
Sample genotype (not yours): T/T
Highly Elevated Psoriasis Risk
Two copies of the T allele are associated with an estimated 4-fold increase in the risk of developing psoriasis. This genotype also provides enhanced viral defense but raises the risk of type 2 diabetes.
What this genotype means: ~4x increased risk of psoriasis; Slower progression to AIDS if infected with HIV; Increased risk of type 2 diabetes.
Gene function and biological role
Gene Function: LOC112267902 is an uncharacterized long non-coding RNA gene located within the highly complex major histocompatibility complex region on chromosome 6. This genomic neighborhood is essential for regulating human immune responses and antigen presentation. It lies in close proximity to the HLA-C gene, which encodes a critical class I major histocompatibility complex receptor [1]. The HLA-C receptor displays intracellular peptides to cytotoxic T cells, helping the immune system distinguish healthy self-cells from foreign invaders [2]. Variations in this genetic region are heavily implicated in susceptibility to autoimmune diseases and differences in viral defense [3].
Variant Impact: The rs10484554 variant is a non-coding single nucleotide polymorphism located upstream of the HLA-C gene. It serves as a highly reliable genetic proxy for the HLA-Cw*06:02 allele, which is the single strongest genetic risk factor for psoriasis [1]. This genetic change is thought to influence the expression and regulation of nearby immune-related genes [2]. Beyond its prominent role in skin inflammation, the variant is also associated with how effectively the immune system controls viral replication [3].
Key Insight: This variant represents a classic evolutionary trade-off, significantly increasing the risk of psoriasis while simultaneously helping the immune system control viral replication.
Location: HLA-C. Chromosome 6 · 6p21.33 · 31.3 Mb
Estimated prevalence by population
Global 76.8%; European 75.0%; African 80.2%; East Asian 89.9%; South Asian 69.9%; Americas 79.5%; Ashkenazi 47.8%; Finnish 81.0%; Middle Eastern 58.8%; Amish 60.6%.
Estimated CC genotype frequency.
Global 21.5%; European 23.2%; African 18.7%; East Asian 9.9%; South Asian 27.4%; Americas 19.3%; Ashkenazi 42.7%; Finnish 18.0%; Middle Eastern 35.7%; Amish 34.5%.
Estimated CT genotype frequency.
Global 1.7%; European 1.8%; African 1.1%; East Asian 0.3%; South Asian 2.7%; Americas 1.2%; Ashkenazi 9.5%; Finnish 1.0%; Middle Eastern 5.4%; Amish 4.9%.
Estimated TT genotype frequency.
Showing effects for C/C genotype
Organ Systems
Skin & Hair Conditions
Psoriasis. Evidence: 10/10. Source: PMID 18369459. Typical Risk.
Immunity & Inflammation
Infection Susceptibility & Resistance
HIV Control. Evidence: 4/10. Source: PMID 19115949. Typical Progression.
Autoimmune Diseases
Rheumatoid Arthritis. Evidence: 3/10. Source: PMID 24566686. Typical Risk.
Cardiovascular & Metabolic
Diabetes & Glycemic Traits
Type 2 Diabetes. Evidence: 8/10. Source: PMID 33385400. Typical Risk.
Showing effects for C/T genotype
Psoriasis. Evidence: 10/10. Source: PMID 18369459. ~2.8x Increased Risk.
HIV Control. Evidence: 4/10. Source: PMID 19115949. Slower Progression.
Rheumatoid Arthritis. Evidence: 3/10. Source: PMID 24566686. Decreased Risk.
Type 2 Diabetes. Evidence: 8/10. Source: PMID 33385400. Slightly Increased.
Showing effects for T/T genotype
Psoriasis. Evidence: 10/10. Source: PMID 18369459. ~4x Increased Risk.
Type 2 Diabetes. Evidence: 8/10. Source: PMID 33385400. Increased Risk.
What this genotype means for the people who carry it
Sample genotype: CC (Homozygous)
Having the CC genotype is the most common genetic profile globally, occurring in approximately 88% of the population. This genotype is associated with a typical baseline risk for developing cutaneous psoriasis [1]. It lacks the T allele, which is a strong proxy for the HLA-Cw*06:02 risk variant [2]. Consequently, individuals with this profile do not experience the genetic predisposition to early-onset psoriasis or psoriatic arthritis seen in carriers [3]. However, this typical profile also means lacking the protective immune response against certain viral infections that the T allele provides [4].
Typical baseline risk for psoriasis; Standard viral progression rate.
Sample genotype: CT (Heterozygous)
Carrying one copy of the T allele significantly increases susceptibility to cutaneous psoriasis, with studies showing an approximate 2.8-fold increase in risk [1]. This variant is a strong marker for the HLA-Cw*06:02 allele, which is the single most dominant genetic risk factor for psoriasis [2]. Individuals with this genotype are more likely to experience an earlier onset of skin symptoms, often before the age of puberty [3]. On the other hand, this same immune profile is associated with a beneficial effect in viral defense, specifically showing slower progression to AIDS in the event of an HIV infection [4]. It is also linked to a slightly higher risk of type 2 diabetes [5].
~2.8x increased risk of psoriasis; Slower progression to AIDS if infected with HIV.
Sample genotype: TT (Homozygous)
Having two copies of the T allele carries the highest genetic predisposition to psoriasis, with studies estimating a 4-fold increase in risk compared to the common genotype [1]. This homozygous profile strongly correlates with the HLA-Cw*06:02 risk marker, which drives early-onset cutaneous psoriasis and psoriatic arthritis [2]. The immune system in these individuals is highly active, which can lead to autoimmune skin inflammation [3]. However, this heightened immune vigilance also offers a significant advantage in controlling viral replication, leading to slower progression to AIDS [4]. Additionally, this profile is associated with a higher risk of developing type 2 diabetes [5].
~4x increased risk of psoriasis; Slower progression to AIDS if infected with HIV; Increased risk of type 2 diabetes.
Variants with shared genetic architecture
rs12191877 · HLA-C Gene · Chr 6 · Psoriasis Risk
rs9264942 · HLA-C Gene · Chr 6 · Viral Control and Crohn's
rs4406273 · LOC112267902 Gene · Chr 6 · Psoriasis Risk
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
Content updated August 2026.
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