What you carry at this position in your DNA and what research says about it.
Triglycerides and Heart Health: 10/10 evidence, 27 publications.
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Sample genotype (not yours): C/C
Higher Triglycerides and Elevated Diabetes Risk
Having two copies of the C allele is associated with less efficient clearance of fats from your blood. This leads to higher circulating triglycerides, lower HDL cholesterol, and a slightly increased risk of type 2 diabetes.
What this genotype means: Higher circulating triglycerides; Lower HDL cholesterol; Slightly higher risk of type 2 diabetes.
Sample genotype (not yours): C/T
Typical Lipid Profile and Diabetes Risk
Carrying one copy of the T allele provides a moderate benefit, helping to keep your triglyceride and cholesterol levels within a typical range. Your genetic risk for type 2 diabetes is also average.
What this genotype means: Typical triglyceride levels; Typical HDL cholesterol levels; Average risk of type 2 diabetes.
Sample genotype (not yours): T/T
Optimal Lipid Profile and Lower Diabetes Risk
Carrying two copies of the T allele is associated with highly efficient fat clearance from the bloodstream. This results in lower triglycerides, higher HDL cholesterol, and a reduced risk of type 2 diabetes.
What this genotype means: Lower circulating triglycerides; Higher HDL cholesterol; Reduced risk of type 2 diabetes.
Gene function and biological role
Gene Function: Encoding the lipoprotein lipase enzyme, the LPL gene is essential for lipid metabolism [1]. This enzyme plays a critical role by hydrolyzing triglycerides carried in chylomicrons and very-low-density lipoproteins into free fatty acids [2]. These released fatty acids are then utilized by surrounding tissues for energy production or stored as fat [1]. By breaking down these triglyceride-rich particles, lipoprotein lipase also facilitates the maturation and elevation of high-density lipoprotein (HDL) cholesterol [3]. Consequently, genetic variations that alter LPL expression or activity can significantly impact circulating lipid profiles and cardiovascular risk [4].
Variant Impact: Located on chromosome 8 near the LPL gene, rs10096633 is an intergenic genetic marker [1]. This single nucleotide polymorphism is in strong linkage disequilibrium with functional variants in the LPL gene, meaning it serves as a highly reliable proxy for LPL enzyme efficiency [4]. The C allele is associated with higher levels of circulating triglycerides and lower levels of HDL cholesterol [2]. Conversely, the T allele is linked to more efficient triglyceride clearance and higher HDL cholesterol levels [3]. Because of its strong influence on lipid clearance, this variant is also associated with downstream metabolic outcomes, including the risk of developing type 2 diabetes [5].
Key Insight: This variant acts as a genetic proxy for lipoprotein lipase efficiency, directly influencing how quickly your body clears dietary fats from the bloodstream. Carrying the protective T allele not only lowers triglycerides but also naturally boosts HDL cholesterol and reduces type 2 diabetes risk.
Location: LPL. Chromosome 8 · 8p21.3 · 20.0 Mb
Estimated prevalence by population
Global 64.2%; European 76.2%; African 33.1%; East Asian 79.6%; South Asian 79.2%; Americas 74.0%; Ashkenazi 63.6%; Finnish 80.7%; Middle Eastern 67.7%; Amish 63.2%.
Estimated CC genotype frequency.
Global 29.6%; European 22.2%; African 48.9%; East Asian 19.3%; South Asian 19.6%; Americas 24.1%; Ashkenazi 32.3%; Finnish 18.3%; Middle Eastern 29.1%; Amish 32.6%.
Estimated CT genotype frequency.
Global 6.2%; European 1.6%; African 18.1%; East Asian 1.2%; South Asian 1.2%; Americas 2.0%; Ashkenazi 4.1%; Finnish 1.0%; Middle Eastern 3.1%; Amish 4.2%.
Estimated TT genotype frequency.
Showing effects for C/C genotype
Cardiovascular & Metabolic
Lipids & Cholesterol
Triglycerides. Evidence: 10/10. Source: PMID 19060911. Higher Levels.
HDL Cholesterol. Evidence: 10/10. Source: PMID 21347282. Lower Levels.
LDL Cholesterol. Evidence: 9/10. Source: PMID 35213538. Higher Levels.
Diabetes & Glycemic Traits
Type 2 Diabetes. Evidence: 7/10. Source: PMID 30297969. Slightly Higher Risk.
Showing effects for C/T genotype
Triglycerides. Evidence: 10/10. Source: PMID 19060911. Typical Levels.
HDL Cholesterol. Evidence: 10/10. Source: PMID 21347282. Typical Levels.
LDL Cholesterol. Evidence: 9/10. Source: PMID 35213538. Typical Levels.
Type 2 Diabetes. Evidence: 7/10. Source: PMID 30297969. Typical Risk.
Showing effects for T/T genotype
Triglycerides. Evidence: 10/10. Source: PMID 19060911. Lower Levels.
HDL Cholesterol. Evidence: 10/10. Source: PMID 21347282. Higher Levels.
LDL Cholesterol. Evidence: 9/10. Source: PMID 35213538. Lower Levels.
Type 2 Diabetes. Evidence: 7/10. Source: PMID 30297969. Slightly Lower Risk.
What this genotype means for the people who carry it
Sample genotype: CC (Homozygous)
A genetic profile with two copies of the C allele is the most common globally. Large-scale genome-wide association studies have consistently linked this profile to less efficient lipoprotein lipase activity [1]. As a result, individuals with this genotype tend to have higher circulating levels of triglycerides and lower levels of protective HDL cholesterol [2]. These lipid imbalances can contribute to a higher risk of cardiovascular issues over time [3]. Additionally, this genetic profile is associated with a slightly elevated risk of developing type 2 diabetes [4]. Maintaining a healthy diet low in simple sugars and engaging in regular physical activity are particularly beneficial strategies for managing lipid levels with this genetic background [5].
Higher circulating triglycerides; Lower HDL cholesterol; Slightly higher risk of type 2 diabetes.
Sample genotype: CT (Heterozygous)
An intermediate genetic profile with one C allele and one T allele represents a balanced state. Research indicates that individuals with this profile generally exhibit intermediate lipoprotein lipase activity [1]. Consequently, circulating levels of triglycerides and HDL cholesterol tend to fall within the typical population average [2]. This intermediate activity also translates to a standard, baseline risk for cardiovascular conditions and type 2 diabetes [3]. While you do not have the maximum lipid-lowering benefits of the double-T genotype, you are partially protected against the higher lipid levels seen in C/C homozygotes [4]. Standard lifestyle recommendations, including a balanced diet and regular exercise, remain highly effective for maintaining optimal metabolic health [5].
Typical triglyceride levels; Typical HDL cholesterol levels; Average risk of type 2 diabetes.
Sample genotype: TT (Homozygous)
A double-T genetic profile is the least common globally but offers significant metabolic advantages. Having two copies of the T allele is strongly associated with highly efficient lipoprotein lipase enzyme activity [1]. This enhanced efficiency allows your body to clear dietary triglycerides from the bloodstream rapidly, resulting in lower circulating triglyceride levels [2]. Furthermore, this process naturally boosts high-density lipoprotein (HDL) cholesterol, which helps protect blood vessels [3]. Studies have also demonstrated that this genetic profile is associated with a reduced risk of developing type 2 diabetes [4]. Regular physical activity has been shown to synergize exceptionally well with this genotype, further enhancing cardiovascular protection [5].
Lower circulating triglycerides; Higher HDL cholesterol; Reduced risk of type 2 diabetes.
Variants with shared genetic architecture
rs115849089 · LPL Gene · Chr 8 · Triglyceride Levels
rs12678919 · LPL Gene · Chr 8 · Cholesterol and Lipids
rs13702 · LPL Gene · Chr 8 · Blood Triglyceride Levels
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
Content updated August 2026.
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