Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Voriconazole is an azole antifungal: it blocks the fungal enzyme that makes ergosterol, a building block of the fungal cell membrane. It is used for serious fungal infections such as invasive aspergillosis and some Candida infections, often in people whose immune system is weakened. It is sold as Vfend, among other names.
Voriconazole is broken down mainly by the liver enzyme CYP2C19, and its blood levels vary widely between people. Poor metabolizers keep much more of it, with a higher chance of side effects such as visual disturbances and liver effects; people with the fast *17 version on both copies (ultrarapid metabolizers) may clear it too quickly for it to reach working levels. CPIC and DPWG have published guidelines on CYP2C19 and voriconazole, and the US FDA lists it as affecting safety. Studies have also looked at CYP3A4 and other genes, with weaker evidence.
Clinical guidelines that name a gene for Voriconazole. They sort people into groups by the gene copies they carry.
Every published finding on gene variants and Voriconazole. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3, CYP2C19*17: Level 1A · replicated. Metabolism/PK. 47.
SLCO2B1 rs3781727: Level 3. Metabolism/PK. 1.
CYP3A4 rs4646437: Level 3. Metabolism/PK: Fungal infectious disease. 1.
ABCB1 rs1045642: Level 3. Metabolism/PK. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Agenerase (Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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