Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Venetoclax is a BCL-2 inhibitor: it blocks BCL-2, a protein that keeps many blood cancer cells from dying, so they self-destruct. It is used for chronic lymphocytic leukaemia and, with azacitidine or low-dose cytarabine, for acute myeloid leukaemia in people who cannot have intensive chemotherapy. Treatment starts slowly to avoid tumour lysis syndrome. It is sold as Venclexta and Venclyxto.
Venetoclax is broken down mainly by CYP3A4 (with CYP3A5), so strong CYP3A4 blockers raise its levels many-fold. The gene study listed looked at CYP3A5 for its levels. Resistance arises from acquired changes in BCL2 and related genes in the cancer cells. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Venetoclax. Upload your DNA file to see which of these rows apply to you.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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