Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Trimipramine is a tricyclic antidepressant (TCA) with a strong calming, sleep-promoting effect, because it also blocks histamine. It is used for depression, especially when sleep problems or anxiety are prominent. It is sold as Surmontil and Stangyl, among other names.
Trimipramine is broken down by the liver enzymes CYP2C19 and CYP2D6. People with little or no CYP2D6 activity build up higher levels, and CYP2C19 variants shift how much is turned into its active breakdown product. CPIC has published a guideline on CYP2D6 and CYP2C19 for the tricyclics, including trimipramine, and the US FDA lists an effect on drug levels. A few other genes have been studied, with weaker evidence.
Clinical guidelines that name a gene for Trimipramine. They sort people into groups by the gene copies they carry.
Every published finding on gene variants and Trimipramine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2D6 CYP2D6*1, CYP2D6*3, CYP2D6*4, CYP2D6*5, CYP2D6*6: Level 1A · replicated. Metabolism/PK: Mental Disorders. 4.
CYP2C19 CYP2C19*1, CYP2C19*2: Level 1A · replicated. Metabolism/PK. 2.
CYP2C9 CYP2C9*1, CYP2C9*3: Level 3. Other. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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