Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Tezacaftor is a CFTR corrector: it helps faulty CFTR protein fold properly and reach the cell surface. It is given combined with ivacaftor (Symdeko, Symkevi) and, together with elexacaftor and ivacaftor, in the triple combination Trikafta (Kaftrio), for cystic fibrosis.
Tezacaftor works only for cystic fibrosis caused by particular variants in CFTR, the gene behind the condition, such as F508del and certain residual-function variants listed in the US label. All studies on this page concern CFTR variants. It is broken down mainly by CYP3A4. There is no CPIC or DPWG guideline for tezacaftor itself.
Every published finding on gene variants and Tezacaftor. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CFTR rs75527207: Level 3. Efficacy: Cystic Fibrosis. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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