Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Temsirolimus is an mTOR inhibitor given by weekly drip: the body turns it partly into sirolimus, and both block mTOR, which controls cell growth and blood vessel formation. It is used for advanced kidney cancer, especially with poor-risk features, and in Europe for mantle cell lymphoma. It is sold as Torisel.
Temsirolimus is broken down by CYP3A4 and CYP3A5 and pumped out of cells by ABCB1. The few gene studies on it looked at ABCB1, NR1I2 (the regulator of CYP3A4) and CYP3A5 for its blood levels and side effects. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Temsirolimus. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
NR1I2 rs6785049: Level 3. Toxicity, Metabolism/PK: Gastrointestinal toxicity, Myelosuppression, Urinary Bladder Neoplasms. 1.
ABCB1 rs2032582: Level 3. Metabolism/PK: Hematopoietic stem cell transplantation, Kidney Transplantation, Urinary Bladder Neoplasms. 1.
NR1I2 rs3814055: Level 3. Toxicity, Metabolism/PK: adverse events, Gastrointestinal toxicity, Myelosuppression, Urinary Bladder Neoplasms. 1.
ABCB1 rs1128503: Level 3. Metabolism/PK: Urinary Bladder Neoplasms. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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