Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Taxanes are a class of chemotherapy medicines that stabilise microtubules, the protein fibres that pull chromosomes apart during cell division, so dividing cancer cells get stuck and die. The class includes paclitaxel, docetaxel and cabazitaxel, used for breast, ovarian, lung, prostate, stomach and head and neck cancers. Nerve damage in the hands and feet is a common side effect. This page collects studies on taxanes as a group.
Studies of the class as a whole looked at VEGF pathway genes (VEGFA, EPAS1, FLT1) for response, and at ABCB1 and other genes for side effects such as nerve damage. The findings come from single or a few studies, and there is no CPIC or DPWG guideline. Paclitaxel and docetaxel, each on its own page, have further studies on the enzymes that break them down, such as CYP2C8 and CYP3A4.
Every published finding on gene variants and Taxanes. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
VEGFA rs9369421: Level 3. Toxicity. 1.
VEGFA rs9369421: Level 3. Efficacy: Ovarian Neoplasms. 1.
VEGFA rs879825: Level 3. Toxicity: Ovarian Neoplasms. 1.
GSR rs3594: Level 3. Toxicity: Ovarian Neoplasms. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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