Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Sufentanil is a synthetic opioid of the fentanyl family, several times more potent than fentanyl. It is used in anaesthesia and intensive care, in epidurals during labour, and as a tablet under the tongue for severe acute pain in supervised settings. It is sold as Sufenta and Dsuvia, among other names.
Sufentanil is broken down mainly by CYP3A4. Most studies on it, many from China, looked at how much sufentanil people needed for pain relief after surgery, and linked this to variants in the opioid receptor gene OPRM1 (especially A118G), CYP3A4, ABCB1 and COMT. The results are mixed, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Sufentanil. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP3A4 rs2242480: Level 3. Dosage: Pain. 6.
OPRM1 rs1799971: Level 3. Dosage: Pain, Pain, Postoperative. 4.
COMT rs4680: Level 3. Dosage. 2.
ABCB1 rs2032582: Level 3. Dosage: Pain, Postoperative. 2.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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