Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Rituximab is a biologic medicine, a monoclonal antibody against CD20, a protein on B cells; it marks B cells for destruction by the immune system. It is used for B-cell lymphomas (often in R-CHOP) and chronic lymphocytic leukaemia, and for rheumatoid arthritis, ANCA vasculitis, pemphigus and other autoimmune diseases. It is sold as Rituxan and MabThera, and as biosimilars.
As an antibody, rituximab is not broken down by drug-processing enzymes. The best-studied gene is FCGR3A, the receptor immune cells use to grab antibody-coated cells: its V158F variant (rs396991) was linked in several studies to a better response in lymphoma and autoimmune disease, though not consistently. Studies have also looked at FCGR2A, TGFB1 and other immune genes. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Rituxan. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
FCGR3A rs396991: Level 2B · replicated. Efficacy: Neuromyelitis Optica, Rheumatoid arthritis. 3.
FCGR3A rs396991: Level 3. Efficacy. 4.
GSTA1 rs3957357: Level 3. Efficacy: Lymphoma, Large B-Cell, Diffuse. 2.
TGFB1 rs1800471: Level 3. Efficacy: Rheumatoid arthritis. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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