Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Ritonavir is an HIV protease inhibitor that today is used almost only as a booster: in small doses it strongly blocks the liver enzyme CYP3A4, which raises and prolongs the levels of other HIV medicines given with it. It is also the booster in Paxlovid, the COVID-19 treatment with nirmatrelvir. It is sold as Norvir.
Because ritonavir blocks CYP3A4 so strongly, gene differences in that enzyme matter little while it is taken. Studies have looked at the transporters ABCB1 and SLCO1B1 and at CYP3A5 for the levels of ritonavir-boosted medicines, and at fat-metabolism genes (APOC3 and others) for the raised blood fats protease inhibitors can cause. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Ritonavir. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
APOE rs7412: Level 3. Toxicity: HIV infectious disease, Hyperlipidemias, Hypertriglyceridemia. 2.
APOC3 rs2854117: Level 3. Toxicity: HIV infectious disease, Hyperlipidemias. 2.
APOE rs7412: Level 3. Toxicity: HIV infectious disease, Hypertriglyceridemia. 2.
ABCB1 rs2032582: Level 3. Metabolism/PK: HIV infectious disease. 2.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Agenerase (Protease Inhibitors)
Crixivan (Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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