Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Ribociclib is a targeted cancer medicine that blocks CDK4 and CDK6, enzymes that push cells into division. It is used with hormone therapy for hormone receptor-positive, HER2-negative breast cancer, both advanced and, more recently, early-stage after surgery. Because it can lengthen the QT interval, heart tracings are checked. It is sold as Kisqali.
Ribociclib is broken down mainly by CYP3A4 and is carried by ABCB1. The single gene study listed looked at ABCB1 in relation to dose reductions. Whether it is used depends on the hormone receptor and HER2 status of the tumour, tested on tumour tissue. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Ribociclib. Upload your DNA file to see which of these rows apply to you.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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