Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Remifentanil is an ultra-short-acting synthetic opioid of the fentanyl family. Given as a continuous drip during anaesthesia, it wears off within minutes once stopped, because blood and tissue esterases break it down. It is used during surgery and sometimes for pain relief in labour. It is sold as Ultiva, among other names.
Remifentanil is broken down by non-specific esterases in the blood and tissues, not by liver CYP enzymes, so the usual drug-processing genes do not apply. Studies have looked at the transporter ABCB1, the opioid receptor gene OPRM1, COMT and KCNJ6 for how much remifentanil people needed and for side effects. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Remifentanil. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
COMT rs4680: Level 3. Efficacy: Pain. 1.
OPRM1 rs79910351: Level 3. Efficacy. 1.
ABCB1 rs1128503: Level 3. Efficacy, Toxicity: tonsillectomy. 1.
ADRB2 rs1042718: Level 3. Toxicity: Hypotensive disorder. 1.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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