Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Protease inhibitors are a class of antiviral medicines that block a viral protease, the enzyme a virus needs to cut its long protein chains into working parts. HIV protease inhibitors include atazanavir, darunavir and lopinavir, usually boosted with ritonavir or cobicistat; hepatitis C protease inhibitors include glecaprevir and grazoprevir. This page collects studies on HIV protease inhibitors as a group.
The single gene study listed for the class looked at SLC28A2, a nucleoside transporter, for side effects. The better-known gene finding belongs to an individual medicine: UGT1A1*28 and harmless jaundice with atazanavir, which has its own page and guideline. Most protease inhibitors are broken down by CYP3A4, and the boosters block it deliberately. There is no CPIC or DPWG guideline for the class.
Every published finding on gene variants and Protease Inhibitors. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLC28A2 rs11854484: Level 3. Toxicity: Hepatitis C virus infection. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Agenerase (Protease Inhibitors)
Crixivan (Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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