Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Oseltamivir is an antiviral for influenza: it blocks neuraminidase, the enzyme flu viruses use to break free from infected cells, so the virus spreads less within the body. It is used to treat flu when started early and to prevent it after close contact. It is sold as Tamiflu.
Oseltamivir is a prodrug that the liver esterase CES1 turns into its active form, which the kidneys then clear. A study linked the CES1 variant G143E (rs71647871) to much less activation, and another looked at ABCB1 for side effects. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Oseltamivir. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCB1 rs1045642: Level 3. Toxicity. 2.
CES1 rs200707504: Level 3. Metabolism/PK. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Agenerase (Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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