Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Opipramol is a tricyclic medicine that, unlike classic tricyclic antidepressants, does not block monoamine reuptake; it acts mainly on sigma receptors and blocks histamine receptors. It is used in Germany and some other European countries for generalised anxiety and somatoform disorders, where it is sold as Insidon.
Opipramol is broken down mainly by CYP2D6. The gene studies on it linked CYP2D6 poor metabolizer status to higher levels and side effects, from a few case reports and small studies. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Opipramol. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2D6 CYP2D6*1, CYP2D6*4: Level 3. Dosage, Toxicity: Depression. 1.
Studies of how much of the drug people needed or tolerated.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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