Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Mitoxantrone is an anthracenedione, a chemotherapy medicine related to the anthracyclines: it slips between DNA strands and blocks topoisomerase II. It is used for acute myeloid leukaemia and advanced prostate cancer, and, because it also suppresses immune cells, for aggressive forms of multiple sclerosis. Its use is limited by heart damage over a lifetime total. It is sold as Novantrone, among other names.
Mitoxantrone is broken down in the liver and pumped out of cells by ABCG2 and ABCB1. Studies have looked at GALNT14 and SLCO1B1 for response in liver cancer, and at a few genes (such as MECP2) for response in multiple sclerosis. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Mitoxantrone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GALNT14 rs9679162: Level 3. Efficacy: Hepatocellular Carcinoma, Liver cancer. 2.
SLCO1B1 rs2291075: Level 3. Efficacy: Leukemia, Myeloid, Acute. 1.
GALNT14 rs12613732: Level 3. Efficacy: Hepatocellular Carcinoma. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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