Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Mitotane is an adrenolytic medicine, related to the insecticide DDT, that destroys cells of the adrenal cortex and blocks steroid hormone production. It is used for adrenocortical carcinoma, a rare adrenal cancer, after surgery or when it has spread, and sometimes for Cushing's syndrome. Blood levels are monitored, and steroid replacement is needed. It is sold as Lysodren.
Mitotane builds up in fat and strongly speeds up CYP3A4, lowering the levels of many other medicines. The gene study listed linked a CYP2B6 variant (*6) to reaching higher mitotane levels. The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Mitotane. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2B6 rs3745274: Level 3. Other: Adrenocortical Carcinoma. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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