Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Lisinopril is one of the most prescribed ACE inhibitors: it blocks angiotensin-converting enzyme, so less angiotensin II is made, blood vessels relax and the body holds less salt. It is used for high blood pressure, heart failure, after a heart attack and to protect the kidneys in diabetes. A dry cough is a common side effect. It is sold as Zestril and Prinivil, among other names.
Lisinopril is not broken down at all; the kidneys clear it unchanged, so liver-enzyme genes play no part. Studies have looked at ACE and AGT, genes of the system it blocks, for how much blood pressure fell, and at the bradykinin receptor gene BDKRB2 for cough. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Lisinopril. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
rs200148: Level 3. Toxicity: Hypertension. 1.
ACE rs4291: Level 3. Efficacy: Hypertension. 1.
MMP3 rs35068180: Level 3. Efficacy: Hypertension. 1.
BDKRB2 rs1799722: Level 3. Toxicity: Cough, Essential hypertension. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
ACE Inhibitors (class) (ACE Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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