Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Imidapril is an ACE inhibitor: it blocks angiotensin-converting enzyme, so less angiotensin II is made, blood vessels relax and the body holds less salt. It is used for high blood pressure, mainly in Japan and other Asian and European countries; it is not marketed in the US. It is said to cause cough less often than some other ACE inhibitors. It is sold as Tanatril, among other names.
Imidapril is a prodrug converted into its active form, imidaprilat, by liver esterases. The few gene studies on it looked at CYP11B2 (aldosterone synthase) and AGT for blood pressure response, and at the bradykinin receptor gene BDKRB2 for cough. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Imidapril. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP11B2 rs1799998: Level 3. Efficacy: Essential hypertension. 1.
BDKRB2 rs1799722: Level 3. Toxicity: Cough, Essential hypertension. 1.
AGT rs5051: Level 3. Efficacy: Hypertension. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
ACE Inhibitors (class) (ACE Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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