Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Ibrutinib is a Bruton's tyrosine kinase (BTK) inhibitor that blocks a key signal B cells need to survive and multiply. Taken once daily, it is used for chronic lymphocytic leukaemia, mantle cell lymphoma, Waldenström's macroglobulinaemia and chronic graft-versus-host disease. Atrial fibrillation and bleeding are known side effects. It is sold as Imbruvica.
Ibrutinib is broken down almost entirely by CYP3A4, so CYP3A4 blockers raise its levels many-fold. The gene studies listed looked at ABCG2 and CYP2D6 for its levels. Resistance arises from acquired mutations in BTK itself in the cancer cells, not from inherited genes. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Ibrutinib. Upload your DNA file to see which of these rows apply to you.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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